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Medicinal Chemistry of Anticancer Drugs, Second Edition

Avendano, Carmen; Menendez, J. Carlos

ISBN 10: 0444626492 / ISBN 13: 9780444626493
Published by Elsevier Science
Used Condition: Very Good Soft cover
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Bibliographic Details

Title: Medicinal Chemistry of Anticancer Drugs, ...

Publisher: Elsevier Science

Binding: PAPERBACK

Book Condition:Very Good

About this title

Synopsis:

Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents.

Antitumor chemotherapy is a very active field of research, and a huge amount of information on the topic is generated every year. Cytotoxic chemotherapy is gradually being supplemented by a new generation of drugs that recognize specific targets on the surface or inside cancer cells, and resistance to antitumor drugs continues to be investigated. While these therapies are in their infancy, they hold promise of more effective therapies with fewer side effects.

Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a sorely needed update from the point of view of medicinal chemistry and drug design.

  • Presents information in a clear and concise way using a large number of figures
  • Historical background provides insights on how the process of drug discovery in the anticancer field has evolved
  • Extensive references to primary literature

From the Back Cover:

Medicinal Chemistry of Anticancer Drugs, Second Edition, reviews all aspects of drug design and discovery in the cancer field and discusses the different types of cancer treatment and prevention. Organized by the target involved in the primary mechanism of action of each drug, the book focuses on the mechanism of action of antitumor drugs from the molecular point of view and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. Through a mechanistic approach, this valuable guide provides the reader with the principles of modern drug design methods and their application in the cancer field.

Key Features

  • Explains with many clear figures the biological basis of cancer treatment and the role of chemists in developing and improving anticancer drugs
  • Provides historical background alongside a comprehensive and practical guide on cancer research and anticancer drug development
  • Covers drugs used in cancer therapy and those under clinical study
  • Examines different approaches to treating cancer, drug resistance, and cancer prevention

New to This Edition

  • All chapters have been thoroughly rewritten and updated, including new material covering the latest anticancer drug strategies, inclusion of drug trade names, color in figures, and a large number of three-dimensional structures of drug-target complexes to aid mechanistic discussions
  • Comprehensive list of FDA-approved anticancer drugs and their connections to each chapter (Chapter 1)
  • Section describing the chemical foundations of radiotherapy, radioisotope targeting, and drugs used to improve the results of radiotherapy (Chapter 4)
  • New chapter on epigenetic cancer therapy (Chapter 8)
  • Expanded treatment of small molecules acting on kinases involved in signaling pathways (Chapter 10), including new topics such as drugs targeting hepatocyte growth factor receptor (HGFR), fibroblast growth factor receptor (FGFR), anaplastic lymphoma kinase (ALK), JAK-STAT and PRL pathways, tropomyosin receptor kinase (Trk), Bruton's tyrosine kinase (BTK), checkpoint kinases (CHKs), Pim kinases, and transforming growth factor-β (TGF-β)-Smad signaling
  • New sections devoted to topics of current interest in the area of targeted cancer therapy, including proteolytic enzymes as anticancer targets (NEDD 8 activating enzyme, anaphase-promoting complex, aminopeptidase N, and cathepsin); cancer stem cells acting on the Wingless/β-Catenin (Wnt/β-Cat), Notch, and Hedgehog signaling pathways; and drugs that interfere with oncogenic protein-protein interactions, with special emphasis on anticancer drugs acting on apoptotic signaling pathways (Chapter 11)
  • New chapter dealing with biological cancer therapy comprising topics such as monoclonal antibodies, cancer immunotherapy including cancer vaccines, cancer gene therapy, and antisense oligonucleotides (Chapter 12)
  • A more in-depth study of methods for the specific delivery of anticancer drugs into tumors, especially those involving nanotechnologies (Chapter 13)

"About this title" may belong to another edition of this title.

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