Metal Ions in Biological Systems: Volume 29: Biological Properties of Metal Alkyl Derivatives

Sigel, Helmut

ISBN 10: 0824790227 / ISBN 13: 9780824790226
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Synopsis: This volume is devoted to the research area regarding the biological properties of metal alkyl derivatives, offering an authoritative account of this subject by 16 scientists. In 11 chapters, Biological Properties of Metal Alkyl Derivatives highlights, in detail, derivatives of germanium, tin, lead, arsenic, antimony, selenium, tellurium, cobalt (vitamin B12 derivatives) and nickel (coenzyme F430), including the role of (mainly) micro-organisms in their formation. The derivatives of indium, thallium, bismuth, various transition metals and mercury are also covered to some extent, as are those of the non-metals silicon, phosphorus and sulfur, and the haloperoxidase route of the biogenesis of halomethanes by fungi and plants. The properties of these alkyl derivatives, their biosynthesis, including mechanistic aspects, their appearance in waters (rivers, lakes, oceans) and sediments, and their physiological and toxic effects are summarized.

From the Back Cover: Metal Ions in Life Sciences links coordination chemistry and biochemistry in their widest sense and thus increases our understanding of the relationship between the chemistry of metals and life processes. The series reflects the interdisciplinary nature of Biological Inorganic Chemistry and coordinates the efforts of scientists in fields like biochemistry, inorganic and coordination chemistry, molecular and structural biology, enzymology, environmental chemistry, physiology, toxicology, biophysics, pharmacy, and medicine. Consequently, the volumes are an essential source for researchers active in these and related fields as well as teachers preparing courses, e.g., in Bioinorganic Chemistry.

Volume 1, offers in 15 stimulating chapters an authoritative view of the fascinating research on Neurodegenerative Diseases and Metal Ions. Written by 41 internationally recognized experts, ithighlights, supported by 130 illustrations, the recent progress made in understanding the role metal ions play in diseases like transmissible spongiform encephalo­pathies (Creutzfeldt-Jakob and related diseases), Alzheimer's, Parkinson's, Huntington's, Wilson's and Menkes' diseases, as well as in familial amyotrophic lateral sclerosis and others. The interplay between metal ions, catecholamines and the formation of reactive oxygen species resulting in oxidative stress is considered, as is the metalloneurochemistry of zinc and the neurotoxicity of aluminum, cadmium, lead, and mercury. The need for novel drugs which manipulate metal-centered neuropathology is emphasized. With more than 2000 references this book is a vital resource for scientists and advanced students.

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Title: Metal Ions in Biological Systems: Volume 29:...
Publication Date: 1993
Binding: HRD
Book Condition: New

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