Monograph on Genomics of Ageing Gene-Sirt1

Radha Mahendran

ISBN 10: 3846516554 / ISBN 13: 9783846516553

Published by LAP LAMBERT Academic Publishing Okt 2011, 2011

About this Item

Neuware -Ageing is a syndrome of changes that are deleterious, progressive, universal & thus irreversible. SIRT1 gene is a candidate gene, involved in ageing process. The SIRT1 gene, whose activity is modified by the body's metabolic state & was previously known to help control the process of ageing and extend the lifespan of humans, also plays a key role in regulating the internal clock. This important discovery helps to explain how the body regulates essential functions such as hormone production, body temperature & blood pressure, & may eventually lead to drugs to combat metabolic disorders, obesity or diabetes. SIRT1 gene codes for the protein ¿SIRTUINS¿. By using Bioinformatics Tools & Softwares Exons, Introns, SNPs & RFLPs of SIRT1 were predicted. SNPs are consequently important in understanding human health. Information related to functional SNPs in candidate disease genes is critical for cost effective genetic association studies, which attempt to understand the genetics of complex diseases. The 3D structure of Sirtuin was modeled & Docked with suitable ligands. The SIRT1 activation study helps in medical application for developing SIRT1 activating drugs for ageing problems.Books on Demand GmbH, Überseering 33, 22297 Hamburg 160 pp. Englisch.

Seller Inventory # 9783846516553

Bibliographic Details

• Title: Monograph on Genomics of Ageing Gene-Sirt1
• Publisher: LAP LAMBERT Academic Publishing Okt 2011
• Publication Date: 2011
• Language: English
• ISBN 10: 3846516554
• ISBN 13: 9783846516553
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 220W x 150H x 10D millimeters 220 millimeters width by 150 millimeters height by 10 millimeters depth
• Weight: 256 grams

About this title

Synopsis

Ageing is a syndrome of changes that are deleterious, progressive, universal & thus irreversible. SIRT1 gene is a candidate gene, involved in ageing process. The SIRT1 gene, whose activity is modified by the body's metabolic state & was previously known to help control the process of ageing and extend the lifespan of humans, also plays a key role in regulating the internal clock. This important discovery helps to explain how the body regulates essential functions such as hormone production, body temperature & blood pressure, & may eventually lead to drugs to combat metabolic disorders, obesity or diabetes. SIRT1 gene codes for the protein ‘SIRTUINS’. By using Bioinformatics Tools & Softwares Exons, Introns, SNPs & RFLPs of SIRT1 were predicted. SNPs are consequently important in understanding human health. Information related to functional SNPs in candidate disease genes is critical for cost effective genetic association studies, which attempt to understand the genetics of complex diseases. The 3D structure of Sirtuin was modeled & Docked with suitable ligands. The SIRT1 activation study helps in medical application for developing SIRT1 activating drugs for ageing problems.

About the Author

Ms. Radhamahendran, MSC,M.TECH(PHD), Assistant Professor and Head, Department of Bioinformatics, Velsuniversity, Chennai, India. Her major area of research includes genome analysis, structural bioinformatics, molecular modelling and computer aided drug designing. She has published many articles in reputed journals.