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N-Oxidation of Drugs Biochemistry, pharmacology, toxicology

Peter Hlavica

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ISBN 10: 0412360306 / ISBN 13: 9780412360305
Published by Springer
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Hardcover. 487 pages. Dimensions: 9.3in. x 6.3in. x 1.4in.The metabolic N-oxidation ofnitrogenousxenobiotics has been reported tc occur in many biologicalsystems, in addition to mammaliantissues, and the mechanisms appear to differ in many respects from those involved in oxidative attack atcarbon centres. Theextensive useofnitrogen-containing compounds as pharmaceuticals and chemical intermediates can lead to exposure to alarge numberofthese agentsunderwidelyvaryingconditions. Biotransformation of these xenobiotics by N-oxidative pathways can effect detoxication, butequallywellcaninduceformation ofcytotoxicmetabolites or potential promutagens and procarcinogens. The substantial progress, in recent years, in our understanding ofthe biochemistry and toxicology of N- oxidation of nitrogenous structures has created a need for a synthesis of current knowledge. This book provides a wide-ranging review of the state-of-the-art in nitrogen xenobiochemistry divided into four parts. The introductory chapter discusses recent developments in trace analysis of radical intermediates and other N-oxygenated products by physical and immunochemical techniques. Special attention is given in Part Two to the enzymology of N-oxidation. Thus, detailed account is given of the mechanism and substrate specificity of the flavin-containing mono- oxygenase and factors regulating its activity are addressed. A separate chapter outlines the polymorphic expression of flavoprotein-dependent reactions. Similarly, the mechanistic background and inducibility of cytochrome P-450-catalysed turnover of specific types of nitrogenous compounds is highlighted. Data are also compiled describing the role of peroxidative N-oxidation of xenobiotics in extrahepatic tissues lacking significant amounts ofcytochrome P-450. This item ships from multiple locations. Your book may arrive from Roseburg,OR, La Vergne,TN. Bookseller Inventory # 9780412360305

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Title: N-Oxidation of Drugs Biochemistry, ...

Publisher: Springer

Binding: Hardcover

Book Condition:New

Book Type: Hardcover

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Synopsis:

The metabolic N-oxidation ofnitrogenousxenobiotics has been reported tc occur in many biologicalsystems, in addition to mammaliantissues, and the mechanisms appear to differ in many respects from those involved in oxidative attack atcarbon centres. Theextensive useofnitrogen-containing compounds as pharmaceuticals and chemical intermediates can lead to exposure to alarge numberofthese agentsunderwidelyvaryingconditions. Biotransformation of these xenobiotics by N-oxidative pathways can effect detoxication, butequallywellcaninduceformation ofcytotoxicmetabolites or potential promutagens and procarcinogens. The substantial progress, in recent years, in our understanding ofthe biochemistry and toxicology of N­ oxidation of nitrogenous structures has created a need for a synthesis of current knowledge. This book provides a wide-ranging review of the state-of-the-art in nitrogen xenobiochemistry divided into four parts. The introductory chapter discusses recent developments in trace analysis of radical intermediates and other N-oxygenated products by physical and immunochemical techniques. Special attention is given in Part Two to the enzymology of N-oxidation. Thus, detailed account is given of the mechanism and substrate specificity of the flavin-containing mono­ oxygenase and factors regulating its activity are addressed. A separate chapter outlines the polymorphic expression of flavoprotein-dependent reactions. Similarly, the mechanistic background and inducibility of cytochrome P-450-catalysed turnover of specific types of nitrogenous compounds is highlighted. Data are also compiled describing the role of peroxidative N-oxidation of xenobiotics in extrahepatic tissues lacking significant amounts ofcytochrome P-450.

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The extensive use of nitrogen-containing compounds as pharmaceuticals and chemical intermediates can lead to exposure to a large number of these agents under widely varying conditions. Before elimination the xenobiotics usually undergo biotransformation. Oxidative attack at nitrogen centres can affect detoxification, but equally well can induce formation of cytotoxic metabolites. The substantial progress, in recent years, in our understanding of the biochemistry and toxicology of N-oxidation of nitrogenous structures has created a need for a synthesis of current knowledge. This book aims to provide a wide-ranging review of the state-of-the-art in nitrogen xenobiochemistry divided into four parts: analysis of N-oxidized products; enzymology of N-oxidation; reductions and conjugations of N-oxygenated compounds; and bioactivation of nitrogenous compounds and cell toxity. It is designed to provide the reader with an understanding of the processes associated with exposure to nitrogenous compounds. Written by an international team of experts, this volume is aimed at graduates and research workers in the biochemical, biopharmaceutical and toxicological fields, as well as professionals in the drug, cosmetics, food, chemical and agricultural industries.

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