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Neurodegenerative Disorders: Mechanisms and Prospects for Therapy (Life Sciences Research Report, 51)

Price, D. L.; Thoenen, H.; Aguayo, A.J.

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ISBN 10: 0471929794 / ISBN 13: 9780471929796
Published by John Wiley & Sons Ltd, Englad, 1991
Used Condition: Very Good Ex-Library Cond Book Hardcover
From Mountainview Books, LLC (Hopeland, PA, U.S.A.)

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About this Item

301 pgs. Chapters cover: implications of nematode neuronal cell death for human neurological disorders; the role of excitotoxins in experimental systems and in human neurological disorders; the role of calcium in cel death; what can we learn from the genetics of Alzheimer's disease?; amyloid; are prion diseases useful models for the study of common neurodegenerative disorders?; cell differentiation, axon guidance, and target recognition in vertebrate neural development; the basis of recognition at the synaptic level; neurotrophins; neurite growth inhibitors in the adult mammalian central nervous system; gene replacement therapy; targeted gene expression in transgenic animals; intracerebral implantation of genetically modified cells; intracerebral neural implants; neuronal death and survival; molecular genetic mechanisms of neurological dieases; axonal growth and connectivity; neuronal replacement and functional modification; author index; subject; index. Blue glossy boards. Usual library markings. Clean and tightly bound. Size: 8vo - over 7¾" - 9¾" tall. Bookseller Inventory # B025472

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Bibliographic Details

Title: Neurodegenerative Disorders: Mechanisms and ...

Publisher: John Wiley & Sons Ltd, Englad

Publication Date: 1991

Binding: Hardcover

Book Condition:Very Good Ex-Library Cond Book

Book Type: Book

About this title

Synopsis:

Dahlem Workshop Reports Life Sciences Research Report 51 Neurodegenerative Disorders Mechanisms and Prospects for Therapy Edited by D.L. Price, H. Thoenen and A.J. Aguayo Neurological disorders, particularly the neurodegenerative diseases involving the central nervous system, are characterized by dysfunction and death of specific populations of nerve cells. Cellular and molecular neurobiological strategies have begun to clarify the mechanisms of neuronal degeneration and have led to the design of new approaches to prevent cell degeneration, promote cell survival, and restore the functions of diseased nerve cells. This book provides new information concerning these processes. Background papers review exciting new developments concerning: (a) the mechanisms of neuronal degeneration caused by genetic factors, excitotoxins, and calcium; (b) the molecular pathology leading to abnormalities in Alzheimer’s disease and the spongiform encephalopathies or prion diseases; (c) the biological substrates of cell differentiation, axon guidance, and target recognition during development, repair, and recovery; and (d) the potential therapeutic efficacies of growth factors and grafted cells in re-establishing circuits essential for the restoration of function. The group discussions and background papers in this Dahlem Workshop Report communicate both the excitement and enthusiasm of the participants facing the scientific challenges that are part of this important area of neurobiological research. This volume will be of special interest to professionals in the fields of molecular/cell biology, genetics, neuroanatomy, neurochemistry, developmental neurobiology, and neuropathology as well as clinicians working in neurology and psychiatry. Goal of this Dahlem Workshop: to understand the molecular and cellular mechanisms of neurological disease and to explore new approaches to treatment.

From the Publisher:

Provides a comprehensive examination of the cellular and molecular neurobiological strategies that are used to clarify the mechanisms of neuronal degeneration, which lead to the prevention of cell degeneration, promote cell survival and restore the functions of diseased nerve cells.

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