New Frontiers In Chemical Biology: Enabling Drug Discovery

Bunnage Mark E

Published by Royal Society Of Chemistry
ISBN 10: 184973125X / ISBN 13: 9781849731256
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Despite ever-increasing investment in biomedical research, there has been a significant decline in the number of new drug approvals in recent years. In an effort to improve productivity, the drug discovery community has increasingly looked to biotherapeutics such as antibodies, vaccines, nucleic acids, and peptides.


Chemical biology is an emerging field at the interface between chemistry and biology. It utilises the tools and techniques of chemical synthesis to study and influence biological systems. Recent developments in this area have great potential in addressing the productivity challenges expressed above. For example, chemical biology studies have already led to the identification of novel targets with exciting therapeutic potential and it is clear that the field will prove a key enabler of target discovery in the future. Moreover, the precise synthetic manipulation of biological molecules involved in many chemical biology approaches is now fuelling a new wave of chemically-modified biologics, 'chemologics', with unique properties. In these, and many other ways, chemical biology is a key discipline within 21st century drug discovery and the purpose of this book is to highlight the most important developments. It provides a valuable resource for scientists in academia and industry who are looking to build their knowledge of this hot topic.


The individual chapters cover crucial areas including chemical proteomics, chemical genetics, post-translational modifications, epigenetics, RNA interference, PROTACS, antibody-drug conjugates, and chemologics.

Book Description: Despite ever increasing research investment, there has been a decline in the number of new drug approvals over the last decade. In order to improve productivity, the drug discovery community is exploring alternative approaches. The emerging field of chemical biology utilizes the tools and techniques of chemical synthesis to study and influence biochemical systems. It has already led to the identification of novel therapeutic targets and will continue to facilitate drug discovery in the 21st century. This book highlights the new frontiers in chemical biology and describes their impact and future potential. It provides a valuable resource for scientists in academia and industry who are looking to build their knowledge of this hot topic.

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Bibliographic Details

Title: New Frontiers In Chemical Biology: Enabling ...
Publisher: Royal Society Of Chemistry
Binding: Hb
Book Condition: Brand New
Edition: International Edition.

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