Optimization in Drug Discovery (Methods in Pharmacology and Toxicology)

Humana Press

Published by Humana Press, 2010
ISBN 10: 1617374997 / ISBN 13: 9781617374999
Used / Paperback / Quantity Available: 0
Available From More Booksellers
View all  copies of this book

About the Book

We're sorry; this specific copy is no longer available. AbeBooks has millions of books. We've listed similar copies below.

Description:

We ship International with Tracking Number! May not contain Access Codes or Supplements. Buy with confidence, excellent customer service! L. Bookseller Inventory #

About this title:

Book ratings provided by Goodreads:
0 avg rating
(0 ratings)

Synopsis: Recent analyses of drug attrition rates reveal that a significant number of drug candidates fail in the later stage of clinical development owing to absorption, distribution, metabolism, elimination (ADME), and toxicity issues. Lead optimization in drug discovery, a process attempting to uncover and correct these defects of drug candidates, is highly beneficial in lowering the cost and time to develop therapeutic drugs by reducing drug candidate failures in development. At present, parallel synthesis combining with high-throughput screening has made it easier to generate highly potent compounds (i. e. , hits). However, to be a potential drug, a hit must have drug-like characteristics in addition to potency, which include optimal physicochemical properties, reasonable ph- macokinetic parameters, and good safety profiles. Therefore, research tools must be available in drug discovery to rapidly screen for compounds with favorable drug-like properties, and thus adequate resources can be directed to projects with high potential. Optimization in Drug Discovery: In Vitro Methods is a compilation of detailed experimental protocols necessary for setting up a variety of assays important in compound evaluation. A total of 25 chapters, contributed by many experts in their research areas, cover a wide spectrum of subjects including physicochemical properties, abso- tion, plasma binding, metabolism, drug interactions, and toxicity. A good pharmacokinetic profile has long been recognized as an imp- tant drug-like characteristic. Pharmacokinetic parameters are affected by many properties of drug molecules such as physicochemical nature, abso- tion, metabolic stability, and so on.

From the Back Cover: Although parallel synthesis combined with high-throughput screening has made it easier to generate highly potent drug candidates, many of these compounds never make the grade because they either prove to be unsafe or lack the necessary physicochemical and pharmacokinetic properties. In Optimization in Drug Discovery: In Vitro Methods, a panel of researchers and experts from leading universities and major pharmaceutical companies from all over the world provide proven solutions to this expensive problem with a collection of cutting-edge experimental protocols for early in vitro evaluation of new chemical entities (NCE). These readily reproducible assays measure such critical parameters as physicochemical properties, adsorption, plasma binding, metabolism, drug interactions, and toxicity. All protocols follow the successful Methods in Molecular Biology™ series format, each one offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.
Comprehensive and highly practical, Optimization in Drug Discovery: In Vitro Methods systematically collects and describes the key methods for uncovering-as early in the discovery stage as possible-those defects that can eliminate candidate drugs from preclinical and clinical development.

"About this title" may belong to another edition of this title.

Bibliographic Details

Title: Optimization in Drug Discovery (Methods in ...
Publisher: Humana Press
Publication Date: 2010
Binding: Paperback
Book Condition: Used: Good

Top Search Results from the AbeBooks Marketplace

International Edition
International Edition

1.

Zhengyin Yan
ISBN 10: 1617374997 ISBN 13: 9781617374999
New Paperback Quantity Available: 5
International Edition
Seller
PRIORITY BOOKS
(springfield, VA, U.S.A.)
Rating
[?]

Book Description Paperback. Book Condition: New. Softcover Book, New Condition, Fast Shipping. Ready in Stock. 1st Edition. [Please Read Carefully Before Buying], This Is An International Edition. Printed In Black and White. , Book Cover And ISBN No May Be Different From US Edition. Restricted Sales Disclaimer Wordings Not For Sales In USA And Canada May Be Printed On The Cover Of The Book. Standard Shipping 7-14 Business Days. Expedited Shiping 4-8 Business Days. ***WE DO NOT ENTERTAIN BULK ORDERS.*** The Books May Be Ship From Overseas For Inventory Purpose. Bookseller Inventory # 335646

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 33.86
Convert Currency

Add to Basket

Shipping: US$ 3.99
Within U.S.A.
Destination, Rates & Speeds
International Edition
International Edition

2.

Zhengyin Yan
ISBN 10: 1617374997 ISBN 13: 9781617374999
New Paperback Quantity Available: 1
International Edition
Seller
Nick Book House
(fresno, CA, U.S.A.)
Rating
[?]

Book Description Paperback. Book Condition: New. New, Softcover International Edition, Printed in Black and White, Different ISBN, Same Content As US edition, Book Cover may be Different, in English Language. Bookseller Inventory # 16745

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 33.89
Convert Currency

Add to Basket

Shipping: US$ 3.99
Within U.S.A.
Destination, Rates & Speeds

3.

Published by Humana Press Inc., United States (2010)
ISBN 10: 1617374997 ISBN 13: 9781617374999
New Paperback Quantity Available: 10
Print on Demand
Seller
The Book Depository US
(London, United Kingdom)
Rating
[?]

Book Description Humana Press Inc., United States, 2010. Paperback. Book Condition: New. 1st ed. Softcover of orig. ed. 2004. Language: English . Brand New Book ***** Print on Demand *****. Recent analyses of drug attrition rates reveal that a significant number of drug candidates fail in the later stage of clinical development owing to absorption, distribution, metabolism, elimination (ADME), and toxicity issues. Lead optimization in drug discovery, a process attempting to uncover and correct these defects of drug candidates, is highly beneficial in lowering the cost and time to develop therapeutic drugs by reducing drug candidate failures in development. At present, parallel synthesis combining with high-throughput screening has made it easier to generate highly potent compounds (i. e. , hits). However, to be a potential drug, a hit must have drug-like characteristics in addition to potency, which include optimal physicochemical properties, reasonable ph- macokinetic parameters, and good safety profiles. Therefore, research tools must be available in drug discovery to rapidly screen for compounds with favorable drug-like properties, and thus adequate resources can be directed to projects with high potential. Optimization in Drug Discovery: In Vitro Methods is a compilation of detailed experimental protocols necessary for setting up a variety of assays important in compound evaluation. A total of 25 chapters, contributed by many experts in their research areas, cover a wide spectrum of subjects including physicochemical properties, abso- tion, plasma binding, metabolism, drug interactions, and toxicity. A good pharmacokinetic profile has long been recognized as an imp- tant drug-like characteristic. Pharmacokinetic parameters are affected by many properties of drug molecules such as physicochemical nature, abso- tion, metabolic stability, and so on. Bookseller Inventory # AAV9781617374999

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 175.89
Convert Currency

Add to Basket

Shipping: FREE
From United Kingdom to U.S.A.
Destination, Rates & Speeds

4.

Zhengyin Yan
Published by Humana Press Inc. (2010)
ISBN 10: 1617374997 ISBN 13: 9781617374999
New Quantity Available: > 20
Print on Demand
Seller
Books2Anywhere
(Fairford, GLOS, United Kingdom)
Rating
[?]

Book Description Humana Press Inc., 2010. PAP. Book Condition: New. New Book. Delivered from our UK warehouse in 3 to 5 business days. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000. Bookseller Inventory # LQ-9781617374999

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 176.44
Convert Currency

Add to Basket

Shipping: US$ 11.60
From United Kingdom to U.S.A.
Destination, Rates & Speeds

5.

Published by Humana Press Inc., United States (2010)
ISBN 10: 1617374997 ISBN 13: 9781617374999
New Paperback Quantity Available: 10
Print on Demand
Seller
The Book Depository
(London, United Kingdom)
Rating
[?]

Book Description Humana Press Inc., United States, 2010. Paperback. Book Condition: New. 1st ed. Softcover of orig. ed. 2004. Language: English . Brand New Book ***** Print on Demand *****.Recent analyses of drug attrition rates reveal that a significant number of drug candidates fail in the later stage of clinical development owing to absorption, distribution, metabolism, elimination (ADME), and toxicity issues. Lead optimization in drug discovery, a process attempting to uncover and correct these defects of drug candidates, is highly beneficial in lowering the cost and time to develop therapeutic drugs by reducing drug candidate failures in development. At present, parallel synthesis combining with high-throughput screening has made it easier to generate highly potent compounds (i. e. , hits). However, to be a potential drug, a hit must have drug-like characteristics in addition to potency, which include optimal physicochemical properties, reasonable ph- macokinetic parameters, and good safety profiles. Therefore, research tools must be available in drug discovery to rapidly screen for compounds with favorable drug-like properties, and thus adequate resources can be directed to projects with high potential.Optimization in Drug Discovery: In Vitro Methods is a compilation of detailed experimental protocols necessary for setting up a variety of assays important in compound evaluation. A total of 25 chapters, contributed by many experts in their research areas, cover a wide spectrum of subjects including physicochemical properties, abso- tion, plasma binding, metabolism, drug interactions, and toxicity. A good pharmacokinetic profile has long been recognized as an imp- tant drug-like characteristic. Pharmacokinetic parameters are affected by many properties of drug molecules such as physicochemical nature, abso- tion, metabolic stability, and so on. Bookseller Inventory # AAV9781617374999

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 180.93
Convert Currency

Add to Basket

Shipping: FREE
From United Kingdom to U.S.A.
Destination, Rates & Speeds

6.

ISBN 10: 1617374997 ISBN 13: 9781617374999
New Quantity Available: > 20
Print on Demand
Seller
BWB
(Valley Stream, NY, U.S.A.)
Rating
[?]

Book Description Book Condition: New. This item is Print on Demand - Depending on your location, this item may ship from the US or UK. Bookseller Inventory # POD_9781617374999

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 183.50
Convert Currency

Add to Basket

Shipping: FREE
Within U.S.A.
Destination, Rates & Speeds

7.

Zhengyin Yan
Published by Humana Press Inc. (2010)
ISBN 10: 1617374997 ISBN 13: 9781617374999
New Quantity Available: > 20
Print on Demand
Seller
Pbshop
(Wood Dale, IL, U.S.A.)
Rating
[?]

Book Description Humana Press Inc., 2010. PAP. Book Condition: New. New Book. Shipped from US within 10 to 14 business days. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000. Bookseller Inventory # IQ-9781617374999

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 185.14
Convert Currency

Add to Basket

Shipping: US$ 3.99
Within U.S.A.
Destination, Rates & Speeds

8.

Yan, Zhengyin
Published by Humana Press (2016)
ISBN 10: 1617374997 ISBN 13: 9781617374999
New Paperback Quantity Available: 1
Print on Demand
Seller
Ria Christie Collections
(Uxbridge, United Kingdom)
Rating
[?]

Book Description Humana Press, 2016. Paperback. Book Condition: New. PRINT ON DEMAND Book; New; Publication Year 2016; Not Signed; Fast Shipping from the UK. No. book. Bookseller Inventory # ria9781617374999_lsuk

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 189.97
Convert Currency

Add to Basket

Shipping: US$ 4.98
From United Kingdom to U.S.A.
Destination, Rates & Speeds

9.

ZHENGYIN YAN
Published by Humana Press (2010)
ISBN 10: 1617374997 ISBN 13: 9781617374999
New Paperback Quantity Available: 1
Seller
Herb Tandree Philosophy Books
(Stroud, GLOS, United Kingdom)
Rating
[?]

Book Description Humana Press, 2010. Paperback. Book Condition: NEW. 9781617374999 This listing is a new book, a title currently in-print which we order directly and immediately from the publisher. Bookseller Inventory # HTANDREE0308938

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 201.26
Convert Currency

Add to Basket

Shipping: US$ 10.30
From United Kingdom to U.S.A.
Destination, Rates & Speeds

10.

Yan, Zhengyin [Editor]; Caldwell, Gary W. [Editor];
Published by Humana Press (2010)
ISBN 10: 1617374997 ISBN 13: 9781617374999
New Paperback Quantity Available: 10
Seller
Ergodebooks
(RICHMOND, TX, U.S.A.)
Rating
[?]

Book Description Humana Press, 2010. Paperback. Book Condition: New. Bookseller Inventory # INGM9781617374999

More Information About This Seller | Ask Bookseller a Question

Buy New
US$ 223.22
Convert Currency

Add to Basket

Shipping: US$ 3.99
Within U.S.A.
Destination, Rates & Speeds

There are 2 more copies of this book

View all search results for this book