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Optimized Response-Adaptive Clinical Trials: Sequential Treatment Allocation Based on Markov Decision Problems (BestMasters)

Thomas Ondra

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ISBN 10: 3658083433 / ISBN 13: 9783658083434
Published by Springer Spektrum, 2014
New Condition: New Soft cover
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Bibliographic Details

Title: Optimized Response-Adaptive Clinical Trials:...

Publisher: Springer Spektrum

Publication Date: 2014

Binding: Paperback

Book Condition: New

Edition: 2015.

About this title

Synopsis:

Two-armed response-adaptive clinical trials are modelled as Markov decision problems to pursue two overriding objectives: Firstly, to identify the superior treatment at the end of the trial and, secondly, to keep the number of patients receiving the inferior treatment small. Such clinical trial designs are very important, especially for rare diseases. Thomas Ondra presents the main solution techniques for Markov decision problems and provides a detailed description how to obtain optimal allocation sequences.

About the Author:

Thomas Ondra obtained his Master of Science degree in mathematics at University of Vienna. He is a research assistant and PhD student at the Section for Medical Statistics of Medical University of Vienna.

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