Pharmaceutical Salts and Co-crystals: RSC (Drug Discovery)

Johan Wouters and Luc Quéré

Published by Royal Society of Chemistry, 2011
ISBN 10: 1849731586 / ISBN 13: 9781849731584
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Synopsis: From crystal structure prediction to totally empirical screening, the quest for new crystal forms has become one of the most challenging issues in the solid state science and particularly in the pharmaceutical world. In this context, multi-component crystalline materials like co-crystals have received renewed interest as they offer the prospect of optimized physical properties. As illustrated in this first book_ entirely dedicated to this emerging class of pharmaceutical compounds_ the outcome of such endeavours into crystal engineering have demonstrated clear impacts on production, marketing and intellectual property protection of active pharmaceutical ingredients (APIs). Indeed, co-crystallization influences relevant physico-chemical parameters (such as solubility, dissolution rate, chemical stability, melting point, hygroscopicity, à) and often offers solids with properties superior to those of the free drug. Combining both reports of the latest research and comprehensive overviews of basic principles, with contributions from selected experts in both academia and industry, this unique book is an essential reference, ideal for pharmaceutical development scientists and graduate students in pharmaceutical science.

From the Back Cover: Multi-component crystalline materials (salts and co-crystals) have received renewed interest in recent years due to their importance in the pharmaceutical industry. Pharmaceutical salts and co-crystals represent an emerging class of pharmaceutical materials offering the prospect of optimized physical properties giving new stable and patentable solid forms. Indeed these multi-component crystalline forms influence relevant physico-chemical parameters such as solubility, dissolution rate, chemical and physical stability, melting point and hygroscopicity, which can result in solids with properties superior to those of the free drug. This unique book focuses on the currently 'hot topic' of Pharmaceutical Salts and Co-crystals and covers the following key topics: the fundamental aspects of salts and co-crystals; the role of fluorine in weak interactions in co-crystals; polymorph prediction of small organic molecules, co-crystals and salts; shape and polarity in co-crystal formation; the role of co-crystals in pharmaceutical development; solid forms and pharmacokinetics; the application of mechanochemistry in the synthesis and discovery of new pharmaceutical forms; co-crystallization in solution and scale-up; analytical techniques and strategies for salt/co-crystal characterization; co-crystal solubility and thermodynamic stability; application of phase diagrams in co-crystal search and preparation; limits of the co-crystal concept and beyond; commercial opportunities and patent considerations; using Piracetam as a learning model and monographs of the most frequent co-crystal formers. Combining both reports of the latest academic research and comprehensive overviews of basic principles, with more applied contributions from selected experts in industry. This blend of expertise makes this book an essential reference for pharmaceutical development scientists, researchers in crystal engineering, and is equally useful for the more seasoned expert as well as for the graduate student.

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Title: Pharmaceutical Salts and Co-crystals: RSC (...
Publisher: Royal Society of Chemistry
Publication Date: 2011
Binding: Hardcover
Book Condition: Used: Good

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Johan Wouters, Luc Quere, Salvatore Guccione, David E. Thurston, David Fox
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Book Description Royal Society of Chemistry. Hardback. Book Condition: new. BRAND NEW, Pharmaceutical Salts and Co-crystals, Johan Wouters, Luc Quere, Salvatore Guccione, David E. Thurston, David Fox, From crystal structure prediction to totally empirical screening, the quest for new crystal forms has become one of the most challenging issues in the solid state science and particularly in the pharmaceutical world. In this context, multi-component crystalline materials like co-crystals have received renewed interest as they offer the prospect of optimized physical properties. As illustrated in this first book_ entirely dedicated to this emerging class of pharmaceutical compounds_ the outcome of such endeavours into crystal engineering have demonstrated clear impacts on production, marketing and intellectual property protection of active pharmaceutical ingredients (APIs). Indeed, co-crystallization influences relevant physico-chemical parameters (such as solubility, dissolution rate, chemical stability, melting point, hygroscopicity, a) and often offers solids with properties superior to those of the free drug. Combining both reports of the latest research and comprehensive overviews of basic principles, with contributions from selected experts in both academia and industry, this unique book is an essential reference, ideal for pharmaceutical development scientists and graduate students in pharmaceutical science. Bookseller Inventory # B9781849731584

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Book Description Royal Society Of Chemistry, United Kingdom, 2011. Hardback. Book Condition: New. Language: English . Brand New Book. From crystal structure prediction to totally empirical screening, the quest for new crystal forms has become one of the most challenging issues in the solid state science and particularly in the pharmaceutical world. In this context, multi-component crystalline materials like co-crystals have received renewed interest as they offer the prospect of optimized physical properties. As illustrated in this first book entirely dedicated to this emerging class of pharmaceutical compounds the outcome of such endeavours into crystal engineering have demonstrated clear impacts on production, marketing and intellectual property protection of active pharmaceutical ingredients (APIs). Indeed, co-crystallization influences relevant physico-chemical parameters (such as solubility, dissolution rate, chemical stability, melting point, hygroscopicity, a) and often offers solids with properties superior to those of the free drug. Combining both reports of the latest research and comprehensive overviews of basic principles, with contributions from selected experts in both academia and industry, this unique book is an essential reference, ideal for pharmaceutical development scientists and graduate students in pharmaceutical science. Bookseller Inventory # AAJ9781849731584

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Book Description Royal Society Of Chemistry, United Kingdom, 2011. Hardback. Book Condition: New. Language: English . Brand New Book. From crystal structure prediction to totally empirical screening, the quest for new crystal forms has become one of the most challenging issues in the solid state science and particularly in the pharmaceutical world. In this context, multi-component crystalline materials like co-crystals have received renewed interest as they offer the prospect of optimized physical properties. As illustrated in this first book entirely dedicated to this emerging class of pharmaceutical compounds the outcome of such endeavours into crystal engineering have demonstrated clear impacts on production, marketing and intellectual property protection of active pharmaceutical ingredients (APIs). Indeed, co-crystallization influences relevant physico-chemical parameters (such as solubility, dissolution rate, chemical stability, melting point, hygroscopicity, a) and often offers solids with properties superior to those of the free drug. Combining both reports of the latest research and comprehensive overviews of basic principles, with contributions from selected experts in both academia and industry, this unique book is an essential reference, ideal for pharmaceutical development scientists and graduate students in pharmaceutical science. Bookseller Inventory # AAJ9781849731584

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Wouters, Johan [Editor]; Quéré, Luc [Editor]; Thurston, David E [Series Editor]; Zaworotko, Mike [Contributor]; Bond, Andrew [Contributor]; Guru Row, T.N. [Contributor]; Rodriguez-Hornedo, Nair [Contributor]; Coquerel, Gerard [Contributor]; Hilfiker, Rolf [Contributor]; Rager, Timo [Contributor]; Jones, Bill [Contributor]; Reutzel-Edens, Susan M [Contributor]; Hilden, Lori [Contributor]; Tilborg, Anaelle [Contributor]; Leusen, F JJ [Contributor]; Fabian, Laszlo [Contributor]; Puel, François [Contributor]; Jurgen, Hassa [Contributor]; Desiraju, Gautam [Contributor]; Wermuth, Camille Georges [Contributor]; Biswas, Nilanjana [Contributor]; Schultheiss, Nathan [Contributor];
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