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Pharmacokinetics and Bioavailability of Silymarin

Muhammad Usman

ISBN 10: 384430004X / ISBN 13: 9783844300048
Published by LAP LAMBERT Academic Publishing
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Paperback. 136 pages. Dimensions: 8.7in. x 5.9in. x 0.3in.Silymarin is a purified extract from milk thistle (Silybum marianun (L. ) Gaertn), composed of a mixture of isomeric flavonolignans: silybin (its main, active component), isosilybin, silydianin and silychristin. This extract has been empirically used as a remedy for almost 2000 years, and remains being used as a medicine for many types of acute and chronic liver diseases. Despite its routinely clinical use as hepatoprotectant, the mechanisms underlying its beneficial effects remain largely unknown. The purpose of this study was to investigate the pharmacokinetics and bioaequivalence of two brands of Silymarin tablets in healthy male volunteers in local population. Pharmacokinetic parameters were calculated by non- compartmental method using Kinetica PKPD version 4. 4 and MS Excel Windows professional XP. Maximum concentration of Silymarin in plasma (Cmax), time to these peak plasma concentrations (Tmax) and other bioparameters (AUC0-, AUMC0-, t12, Ke, MRT, Vd and ClT) were determined. This item ships from multiple locations. Your book may arrive from Roseburg,OR, La Vergne,TN. Bookseller Inventory # 9783844300048

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Bibliographic Details

Title: Pharmacokinetics and Bioavailability of ...

Publisher: LAP LAMBERT Academic Publishing

Binding: Paperback

Book Condition:New

Book Type: Paperback

About this title

Synopsis:

Silymarin is a purified extract from milk thistle (Silybum marianun (L.) Gaertn), composed of a mixture of isomeric flavonolignans: silybin (its main, active component), isosilybin, silydianin and silychristin. This extract has been empirically used as a remedy for almost 2000 years, and remains being used as a medicine for many types of acute and chronic liver diseases. Despite its routinely clinical use as hepatoprotectant, the mechanisms underlying its beneficial effects remain largely unknown. The purpose of this study was to investigate the pharmacokinetics and bioaequivalence of two brands of Silymarin tablets in healthy male volunteers in local population. Pharmacokinetic parameters were calculated by non- compartmental method using KineticaŽ PK/PD version 4.4 and MS Excel Windows professional XP. Maximum concentration of Silymarin in plasma (Cmax), time to these peak plasma concentrations (Tmax) and other bioparameters (AUC0-?, AUMC0-?, t1/2, Ke, MRT, Vd and ClT) were determined.

About the Author:

Muhammad Usman, B.Pharm.,M.Phil(Pharmaceutics),is currently working as a Lecturer of Pharmaceutics in the Department of Pharmacy, The Islamia University of Bahawalpur,Punjab,Pakistan. The areas of special interest include Pharmacokinetics,Novel Drug Delivery systems and Bioanalytical method development and validation.

Muhammad Usman, B.Pharm.,M.Phil(Pharmaceutics),is currently working as a Lecturer of Pharmaceutics in the Department of Pharmacy, The Islamia University of Bahawalpur,Punjab,Pakistan. The areas of special interest include Pharmacokinetics,Novel Drug Delivery systems and Bioanalytical method development and validation.

Muhammad Usman, B.Pharm.,M.Phil(Pharmaceutics),is currently working as a Lecturer of Pharmaceutics in the Department of Pharmacy, The Islamia University of Bahawalpur,Punjab,Pakistan. The areas of special interest include Pharmacokinetics,Novel Drug Delivery systems and Bioanalytical method development and validation.

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