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Inside the Plasma Amine Oxidase

Yanwen Chen

ISBN 10: 3639255682 / ISBN 13: 9783639255683
Published by VDM Verlag
New Condition: New Soft cover
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216 pages. Dimensions: 8.7in. x 5.9in. x 0.5in.The copper-containing amine oxidases, like bovine plasma amine oxidase (BPAO), carry out a transaminative oxidation of primary amines to aldehydes via use of an active site Tyr-derived 2, 4, 5-trihydroxyphenylalanine quinone (TPQ) cofactor. Propargylamine is a potent inactivator of BPAO (IC50 3 M), possibly through active-site modification by the a, -unsaturated aldehyde turnover product, but the simple structure is expected to confer low selectivity. On the basis of the finding by previous students that certain extended conjugation analogs such as 1, 6-diamino-2, 4- hexadiyne and 3-cyanopropargylamine preserve strong inactivation potency, other extended conjugation analogs of propargylamine were evaluated. In particular, 1-amino-2, 4-hexadiynes with a 6-OH rather than 6-NH2 group were found to be potent inhibitors. This item ships from multiple locations. Your book may arrive from Roseburg,OR, La Vergne,TN. Bookseller Inventory # 9783639255683

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Bibliographic Details

Title: Inside the Plasma Amine Oxidase

Publisher: VDM Verlag

Binding: Paperback

Book Condition:New

Book Type: Paperback

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The copper-containing amine oxidases, like bovine plasma amine oxidase (BPAO), carry out a transaminative oxidation of primary amines to aldehydes via use of an active site Tyr-derived 2,4,5-trihydroxyphenylalanine quinone (TPQ) cofactor. Propargylamine is a potent inactivator of BPAO (IC50 = 3 ÁM), possibly through active-site modification by the a,▀-unsaturated aldehyde turnover product, but the simple structure is expected to confer low selectivity. On the basis of the finding by previous students that certain extended conjugation analogs such as 1,6-diamino-2,4- hexadiyne and 3-cyanopropargylamine preserve strong inactivation potency, other extended conjugation analogs of propargylamine were evaluated. In particular, 1-amino-2,4-hexadiynes with a 6-OH rather than 6-NH2 group were found to be potent inhibitors.

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