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Protein Expression in Down Syndrome Brain


Published by Springer, 2002
ISBN 10: 3211837043 / ISBN 13: 9783211837047
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Title: Protein Expression in Down Syndrome Brain

Publisher: Springer

Publication Date: 2002

Binding: Hardcover

Book Condition: New


Brand new book - fast delivery//-//. Bookseller Inventory # ABE-9079058282

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Synopsis: This book presents latest original research work and current opinions on Down syndrome, focussing on the molecular biology of the Down syndrome brain at the protein level, rather than at nucleic acid level, as it is the proteins that do the work, and there is a long and unpredictable way from RNA to protein. The studies used fetal brains with Down syndrome in which no neurodegeneration was found and characterized proteins by two-dimensional gel electrophoresis and mass spectrometry. The book provides new aspects, such as that neuronal density and neurotransmission is unchanged in early life but synaptosomal structures and dendritic spines are already seriously affected at the early second trimester. The presentation of a series of tentative mechanisms for the development of the Down syndrome neurophenotype provides models for present and future thinking on the neurobiology of the Down syndrome brain.

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