Stock Image
Buy New
List Price: US$
Price: US$ 101.45 Convert Currency
Shipping: US$ 3.95 Within U.S.A. Destination, Rates & Speeds
Add to basket

30 Day Returns Policy

Rapid Signaling Of Estrogen To Neuronal Dendrite Spine Formation

Sanchez Angel Matias

ISBN 10: 3847317466 / ISBN 13: 9783847317463
Published by LAP LAMBERT Academic Publishing
New Condition New Paperback
From BuySomeBooks (Las Vegas, NV, U.S.A.) Quantity Available: 20
Available From More sellers View all  copies of this book

Paperback. 92 pages. Dimensions: 8.7in. x 5.9in. x 0.2in.Estrogens are important regulators of neuronal cell morphology and this is thought to be critical for gender-specific differences in brain function and dysfunction. Dendritic spine formation is dependent on actin remodeling by WAVE1 protein, which controls actin polymerization through the Arp-23 complex. We show that 17-estradiol (E2) administration leads to phosphorylation and redistribution of WAVE1 at sites of dendritic spine formation. WAVE1 phosphorylation is found to be triggered by a GiG protein-dependent, rapid extranuclear signaling of ER to SrcRac1Cdk5 that directly phosphorylates WAVE1. After WAVE1 phosphorylation, the Arp-23 complex concentrates at sites of spine formation, where it triggers the local reorganization of actin fibers. In parallel, E2 recruits a G13-dependent pathway to RhoA and ROCK-2, leading to activation of actin remodeling via moesin. Silencing of WAVE1 or of moesin abrogates the increase in dendritic spines induced by E2. In conclusion, our findings indicate that the control of actin polymerization and branching via moesin or WAVE1 is a key function of ER in neurons, which may be particularly relevant for the regulation of dendritic spines. This item ships from multiple locations. Your book may arrive from Roseburg,OR, La Vergne,TN. Bookseller Inventory # 9783847317463

About this title:

Synopsis:

Estrogens are important regulators of neuronal cell morphology and this is thought to be critical for gender-specific differences in brain function and dysfunction. Dendritic spine formation is dependent on actin remodeling by WAVE1 protein, which controls actin polymerization through the Arp-2/3 complex. We show that 17-estradiol (E2) administration leads to phosphorylation and redistribution of WAVE1 at sites of dendritic spine formation. WAVE1 phosphorylation is found to be triggered by a G?i/G? protein-dependent, rapid extranuclear signaling of ER? to Src/Rac1/Cdk5 that directly phosphorylates WAVE1. After WAVE1 phosphorylation, the Arp-2/3 complex concentrates at sites of spine formation, where it triggers the local reorganization of actin fibers. In parallel, E2 recruits a G?13-dependent pathway to RhoA and ROCK-2, leading to activation of actin remodeling via moesin. Silencing of WAVE1 or of moesin abrogates the increase in dendritic spines induced by E2. In conclusion, our findings indicate that the control of actin polymerization and branching via moesin or WAVE1 is a key function of ER? in neurons, which may be particularly relevant for the regulation of dendritic spines.

About the Author: Born in Argentina in 1977, he obtained his degree in Molecular Biology from National University of San Luis in 2004. In 2006 he was incorporated at MCGEL laboratory where he began to study neuronal and breast cancer cell movement, and in 2010 he received the Ph.D. from Pisa University. In 2011 he was incorporated at IMBECU-CONICET Mendoza.

"About this title" may belong to another edition of this title.

Bibliographic Details

Title: Rapid Signaling Of Estrogen To Neuronal ...

Publisher: LAP LAMBERT Academic Publishing

Binding: Paperback

Book Condition: New

Book Type: Paperback

Payment Methods

Payment Methods Accepted by Seller

Visa Mastercard American Express


Seller BuySomeBooks
Address: Las Vegas, NV, U.S.A.

AbeBooks Seller Since May 21, 2012
Seller Rating 5-star rating


Terms of Sale:

We guarantee the condition of every book as it's described on the Abebooks web
sites. If you're dissatisfied with your purchase (Incorrect Book/Not as
Described/Damaged) or if the order hasn't arrived, you're eligible for a refund
within 30 days of the estimated delivery date. If you've changed your mind about a book that you've ordered, please use the Ask bookseller a question link to contact us and we'll respond within 2 business days.

BuySomeBooks is operated by Drive-On-In, Inc., a Nevada co...

[More Information]

Shipping Terms:

Orders usually ship within 1-2 business days. Books are shipped from multiple locations so your order may arrive from Las Vegas,NV, Roseburg,OR, La Vergne,TN, Momence,IL, or Commerce,GA.


Store Description: BuySomeBooks is great place to get your books online. With over eight million titles available we're sure to have what you're looking for. Despite having a large selection of new books available for immediate shipment and excellent customer service, people still tell us they prefer us because of our prices.