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Reactivity of Chelated Dinuclear Platinum(ii) Complexes

Allen Mambanda

ISBN 10: 3847378902 / ISBN 13: 9783847378907
Published by LAP Lambert Academic Publishing
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Paperback. 252 pages. Dimensions: 8.7in. x 5.9in. x 0.6in.The search for new Pt(II) metal drugs is underpinned by an in-depth understanding of the factors controlling the bio-reactivity of the Pt(II) pharmaceuticals. An emerging class of compounds which has shown improved antitumour activity is the multinuclear Pt(II) complexes, epitomized by the favourable reactivity profile of BBR3464 from Prof. Farrells labs. Kinetic data of multinuclear Pt(II) compounds is not extensive. This book, reports the substitution reactions of bis(2-pyridylmethyl)amine-chelated dinuclear Pt(II) complexes linked by diamine bridges. The reactions were studied under pseudo first-order conditions as a function of concentration of nucleophiles and temperature using stopped-flow and UV-visible spectroscopic techniques. In general, the substitution of the coligand by the sulfur containing nucleophiles proceeds via a two-step reaction pathway which is associatively activated. In the studied sets of Pt(II) dinuclears, substitution of the coligands is controlled mainly by steric effects, derived from the molecular conformations of the metal complexes and to a lesser extent by electronic effects. Experimental data is well supported by Quantum mechanical calculations. This item ships from multiple locations. Your book may arrive from Roseburg,OR, La Vergne,TN. Bookseller Inventory # 9783847378907

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Bibliographic Details

Title: Reactivity of Chelated Dinuclear Platinum(ii...

Publisher: LAP Lambert Academic Publishing

Binding: Paperback

Book Condition:New

Book Type: Paperback

About this title

Synopsis:

The search for new Pt(II) metal drugs is underpinned by an in-depth understanding of the factors controlling the bio-reactivity of the Pt(II) pharmaceuticals. An emerging class of compounds which has shown improved antitumour activity is the multinuclear Pt(II) complexes, epitomized by the favourable reactivity profile of BBR3464 from Prof. Farrell's labs. Kinetic data of multinuclear Pt(II) compounds is not extensive. This book, reports the substitution reactions of bis(2-pyridylmethyl)amine-chelated dinuclear Pt(II) complexes linked by diamine bridges. The reactions were studied under pseudo first-order conditions as a function of concentration of nucleophiles and temperature using stopped-flow and UV-visible spectroscopic techniques. In general, the substitution of the coligand by the sulfur containing nucleophiles proceeds via a two-step reaction pathway which is associatively activated. In the studied sets of Pt(II) dinuclears, substitution of the coligands is controlled mainly by steric effects, derived from the molecular conformations of the metal complexes and to a lesser extent by electronic effects. Experimental data is well supported by Quantum mechanical calculations.

About the Author:

Dr. Allen Mambanda studied the mechanism and kinetics of substitution reactions of platinum(II) complexes under Prof. D. Jaganyi in the School of Chemistry, University of KwaZulu-Natal, RSA, obtaining his Ph.D in 2010. He is currently a Lecturer in the same school. Prior, he taught in the Dept. of Chem. Tech. at Midlands State University, Zimbabwe.

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