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Reconstructing Biochemical Systems - Systems modeling and analysis tools for decoding biological designs

Gautam Goel

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ISBN 10: 3836458780 / ISBN 13: 9783836458788
Published by VDM Verlag Dr. Mueller e.K.
New Condition: New Soft cover
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144 pages. Dimensions: 9.5in. x 6.7in. x 0.6in.Revision with unchanged content. The field of biochemical modeling and analysis is faced with an unprecedented flood of experimental data in molecular biology. While the experimental techniques continue to leapfrog ahead in the speed and volume, the methods of analysis and interpretation, however, are still playing catch-up. The notions of systems analysis have found a new foothold, under the banner of Systems Biology, with a promise to uncover the rationale for the designs of biological systems from their parts lists. Aiming to complement hypothesis-driven and reductionistic biological research, and not replace it, a systems biologist relies on the tools of mathematical modeling to be able to contribute meaningfully to any ongoing bio-molecular systems research. The intent of this thesis is to present a framework and toolbox for biochemical systems modeling. The research presented here builds upon the tenets of a well-established approach to biological systems modeling and analysis, called Biochemical Systems Theory (BST), which is almost 40 years old. The thesis presents the features of a MATLAB-based software application that has been built upon the framework of BST and is aptly named as Biochemical Systems Toolbox. This item ships from multiple locations. Your book may arrive from Roseburg,OR, La Vergne,TN. Bookseller Inventory # 9783836458788

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Bibliographic Details

Title: Reconstructing Biochemical Systems - Systems...

Publisher: VDM Verlag Dr. Mueller e.K.

Binding: Paperback

Book Condition:New

Book Type: Paperback

About this title

Synopsis:

Revision with unchanged content. The field of biochemical modeling & analysis is faced with an unpre­cedented flood of experimental data in molecular biology. While the experimental tech­ni­ques continue to leapfrog ahead in the speed & volume, the methods of analysis & interpretation, however, are still playing 'catch-up'. The notions of systems analysis have found a new foothold, under the banner of 'Systems Biology', with a promise to uncover the rationale for the designs of biological systems from their parts lists. Ai­ming to complement hypothesis-driven & reductionistic biological re­search, and not replace it, a systems biologist relies on the tools of mathe­matical modeling to be able to contribute meaningfully to any ongoing bio-molecular systems research. The intent of this thesis is to present a frame­work & toolbox for biochemical systems modeling. The re­search presen­ted here builds upon the tenets of a well-established approach to biological systems modeling & analysis, called Biochemical Systems Theory (BST), which is almost 40 years old. The thesis presents the features of a MATLAB-based software application that has been built upon the framework of BST and is aptly named as Biochemical Systems Toolbox.

About the Author:

I work on computational analysis of metabolic pathways such as glycolysis in lactic acid bacteria. The objective is to uncover regulatory mechanisms of the organism to enable efficient control of metabolite production. Analysis involves mixed-mode modeling (bottom-up/ top-down/ partial modeling & stoichiometric/ kinetic models) & parameter estimation.

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