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Reducing GI Side Effects of NSAIDS by Mutual Prodrug Approach

Sandeep D. Walsangikar

Published by LAP LAMBERT Academic Publishing
ISBN 10: 3846551600 / ISBN 13: 9783846551608
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Title: Reducing GI Side Effects of NSAIDS by Mutual...

Publisher: LAP LAMBERT Academic Publishing

Binding: Paperback

Book Condition: New

Book Type: Paperback

Description:

Paperback. 80 pages. Dimensions: 8.7in. x 5.9in. x 0.2in.Prodrug has been the concept of retro metabolic drug design that incorporates targeting, metabolism and duration of action consideration into the design process. The carboxylic groups of NSAIDs can be temporarily masked and its direct effect on gastric mucosa can be minimized. Ester prodrugs of has been synthesized using various carrier moieties as reduce their GIT irritation and improve bioavailability. Prodrugs of several NSAIDs, such as diclofenac, Aspirin, ketoprofen etc have been synthesized using 1, 4-dihydro-1-methylpyridine-3-carboxylate as a carrier to brain to treat Alzheimers disease. Our aim is to reduce the gastric irritation due to direct contact of the drugs with the gastric mucosa and increased absorption using mutual prodrug approach. This item ships from multiple locations. Your book may arrive from Roseburg,OR, La Vergne,TN. Bookseller Inventory # 9783846551608

About this title:

Synopsis: Prodrug has been the concept of retro metabolic drug design that incorporates targeting, metabolism and duration of action consideration into the design process. The carboxylic groups of NSAIDs can be temporarily masked and its direct effect on gastric mucosa can be minimized. Ester prodrugs of has been synthesized using various carrier moieties as reduce their GIT irritation and improve bioavailability. Prodrugs of several NSAIDs, such as diclofenac, Aspirin, ketoprofen etc have been synthesized using 1, 4-dihydro-1-methylpyridine-3-carboxylate as a carrier to brain to treat Alzheimer?s disease. Our aim is to reduce the gastric irritation due to direct contact of the drugs with the gastric mucosa and increased absorption using mutual prodrug approach.

About the Author: Mr. Walsangikar S. D. has completed his M. Pharmacy in Pharmaceutical Chemistry. He has published various research papers in international journals as author and contributed as co author in various research papers. He has excellant knowledge of synthetic chemistry. Currently he is working as Assistant Professor at GIPER Satara.

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