Statistical Methods for Drug Safety (Chapman & Hall/CRC Biostatistics Series) (Hardcover)

ISBN 10: 146656184X / ISBN 13: 9781466561847
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Explore Important Tools for High-Quality Work in Pharmaceutical Safety

Statistical Methods for Drug Safety presents a wide variety of statistical approaches for analyzing pharmacoepidemiologic data. It covers both commonly used techniques, such as proportional reporting ratios for the analysis of spontaneous adverse event reports, and newer approaches, such as the use of marginal structural models for controlling dynamic selection bias in the analysis of large-scale longitudinal observational data.

Choose the Right Statistical Approach for Analyzing Your Drug Safety Data

The book describes linear and non-linear mixed-effects models, discrete-time survival models, and new approaches to the meta-analysis of rare binary adverse events. It explores research involving the re-analysis of complete longitudinal patient records from randomized clinical trials. The book discusses causal inference models, including propensity score matching, marginal structural models, and differential effects, as well as mixed-effects Poisson regression models for analyzing ecological data, such as county-level adverse event rates. The authors also cover numerous other methods useful for the analysis of within-subject and between-subject variation in adverse events abstracted from large-scale medical claims databases, electronic health records, and additional observational data streams.

Advance Statistical Practice in Pharmacoepidemiology

Authored by two professors at the forefront of developing new statistical methodologies to address pharmacoepidemiologic problems, this book provides a cohesive compendium of statistical methods that pharmacoepidemiologists can readily use in their work. It also encourages statistical scientists to develop new methods that go beyond the foundation covered in the text.

About the Author:

Robert D. Gibbons, PhD, is a professor of biostatistics in the Departments of Medicine, Public Health Sciences, and Psychiatry and director of the Center for Health Statistics at the University of Chicago. He is a fellow of the American Statistical Association (ASA) and a member of the Institute of Medicine of the National Academy of Sciences. He has been a recipient of the ASA’s Outstanding Statistical Application Award and two Youden Prizes.

Anup Amatya, PhD, is an assistant professor in the Department of Public Health Sciences at New Mexico State University. His current research focuses on meta-analysis of sparse binary data and sample size determination in hierarchical non-linear models.

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