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Structural Basis of the L-Carnitine -Butyrobetaine Transport in Cait

Sabrina Schulze

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ISBN 10: 3838126963 / ISBN 13: 9783838126968
Published by Sudwestdeutscher Verlag Fur Hochschulschriften AG
New Condition: New Soft cover
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Paperback. 260 pages. Dimensions: 8.7in. x 5.9in. x 0.6in.Specialized transport proteins in the lipid bilayer perform the translocation of solutes across biological membranes. The prokaryotic L-carnitine-butyrobetaine transporter CaiT is a member of the betainecarnitinecholine transporter (BCCT) family. However, CaiT is an interesting exception within the BCCT family since the transporter functions as a Na- and H- independent antiporter, while most members of the BCCT family require either an additional sodium ion or a proton to transport substrates into the cell. The three-dimensional X-ray crystal structure of CaiT reveals two different substrate-binding sites within the protein and provides insights into important residues that directly interact with the two substrates L-carnitine and -butyrobetaine and enable substrate binding and transport without the need of an additional cation. The comparison of two three-dimension CaiT structures in two different states together with results obtained from functional studies allowed the formulation of a model for the allosterically regulated substrateproduct antiport mechanism in CaiT, which is also very likely conserved in eukaryotic L-carnitine transporters. This item ships from multiple locations. Your book may arrive from Roseburg,OR, La Vergne,TN. Bookseller Inventory # 9783838126968

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Bibliographic Details

Title: Structural Basis of the L-Carnitine -...

Publisher: Sudwestdeutscher Verlag Fur Hochschulschriften AG

Binding: Paperback

Book Condition:New

Book Type: Paperback

About this title

Synopsis:

Specialized transport proteins in the lipid bilayer perform the translocation of solutes across biological membranes. The prokaryotic L-carnitine/γ-butyrobetaine transporter CaiT is a member of the betaine/carnitine/choline transporter (BCCT) family. However, CaiT is an interesting exception within the BCCT family since the transporter functions as a Na+- and H+- independent antiporter, while most members of the BCCT family require either an additional sodium ion or a proton to transport substrates into the cell. The three-dimensional X-ray crystal structure of CaiT reveals two different substrate-binding sites within the protein and provides insights into important residues that directly interact with the two substrates L-carnitine and γ-butyrobetaine and enable substrate binding and transport without the need of an additional cation. The comparison of two three-dimension CaiT structures in two different states together with results obtained from functional studies allowed the formulation of a model for the allosterically regulated substrate/product antiport mechanism in CaiT, which is also very likely conserved in eukaryotic L-carnitine transporters.

About the Author:

Curriculum Vitae: 2005-2010 PhD Thesis at the MPI of Biophysics, Dep. Structural Biology, and Johann-Wolfgang Goethe University, Frankfurt; Supervisor: Prof. Dr. Werner Kühlbrandt2004-2005 Diploma Thesis at the MPI of Physiology, Dep. Structural Biology, Dortmund, and Ruhr-University Bochum; Supervisor: Prof. Dr. Alfred Wittinghofer

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