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Survey of active pharmaceutical ingredients-excipient incompatibility: Nature and mechanism

Tamilvanan Shunmugaperumal

ISBN 10: 3843364931 / ISBN 13: 9783843364935
Published by LAP LAMBERT Academic Publishing, 2010
Condition: Good Soft cover
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Bibliographic Details

Title: Survey of active pharmaceutical ...

Publisher: LAP LAMBERT Academic Publishing

Publication Date: 2010

Binding: Paperback

Book Condition: Good

About this title


To improve physico-chemical properties of an active pharmaceutical ingredient (API) at its preformulation stage, myriad of excipients having defined functional roles like solubility enhancement by co-solvent, micells formation and complexation, intestinal permeability enhancement through the inhibition of efflux transport mechanisms, stability-improvement using pH adjustment, cryo-and lyo-protectants, etc are incorporated into a dosage form containing the API. Although considered primarily as inactive materials, the excipient(s) may react with the API resulting in the development of a detrimental or beneficial substance within the API-loaded dosage form itself. If detrimental substances are formed, then, the issue of API-excipient incompatibility will come up and demand the reformulation of the API, which is costly and time-consuming. This book surveys a comprehensive list of published examples of API-excipient incompatibility relevant to currently or previously marketed drugs. With this coverage, this book also provides first-hand information on the multicomponent nature and complexity of the excipients to the formulation scientist.

About the Author:

Tamilvanan Shunmugaperumal, Ph.D: Studied Pharmacy at Annamalai University, Madras Medical College and Jadavpur University, India. Post-doctoral fellow at Hebrew University of Jerusalem, Israel and University of Antwerp, Belgium. Currently he works in International Medical University, Kuala Lumpur, Malaysia.

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