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Synthesis of Antimalarial Compounds and Their Intermediates

Vivek Jain

ISBN 10: 3639354419 / ISBN 13: 9783639354416
Published by VDM Verlag
New Condition: New Soft cover
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Paperback. 108 pages. Dimensions: 8.6in. x 5.8in. x 0.3in.The resistance of malaria parasites to widely used drugs prompted an upsurge in the development of new drugs with novel mechanism of action, and re- evaluation of the existing drugs to overcome the resistance problem. A number of new potential target pathways have already been identified and efforts to develop lead compounds for these putative targets hopefully will allow treatment of malaria infections in a uniform sustained way. Considerable research efforts were directed in the areas of chloroquine drug resistance reversal agents. Careful development of some bisquinolines, which are free of toxic side effect, 4-anilinoquinolines and modified chloroquine analogs may be helpful to obtain drug candidates that inhibit the growth of chloroquine sensitive and resistant parasites. In the past several years, new structural classes of antimalarial agents, target based antimalarial agents, iron chelators have made some interesting and promising lead molecules available for further optimization to provide compounds for clinical development. This item ships from multiple locations. Your book may arrive from Roseburg,OR, La Vergne,TN. Bookseller Inventory # 9783639354416

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Bibliographic Details

Title: Synthesis of Antimalarial Compounds and ...

Publisher: VDM Verlag

Binding: Paperback

Book Condition:New

Book Type: Paperback

About this title

Synopsis:

The resistance of malaria parasites to widely used drugs prompted an upsurge in the development of new drugs with novel mechanism of action, and re- evaluation of the existing drugs to overcome the resistance problem. A number of new potential target pathways have already been identified and efforts to develop lead compounds for these putative targets hopefully will allow treatment of malaria infections in a uniform sustained way. Considerable research efforts were directed in the areas of chloroquine drug resistance reversal agents. Careful development of some bisquinolines, which are free of toxic side effect, 4-anilinoquinolines and modified chloroquine analogs may be helpful to obtain drug candidates that inhibit the growth of chloroquine sensitive and resistant parasites. In the past several years, new structural classes of antimalarial agents, target based antimalarial agents, iron chelators have made some interesting and promising lead molecules available for further optimization to provide compounds for clinical development.

About the Author:

Yashumati Ratan: Obtained her M. Sc. Pharmaceutical Chemistry from Banasthali University, Rajasthan. Currently working as Assistant Professor at Banasthali University, Rajasthan. Her area of interest is Synthetic Medicinal Chemistry.

Yashumati Ratan: Obtained her M. Sc. Pharmaceutical Chemistry from Banasthali University, Rajasthan. Currently working as Assistant Professor at Banasthali University, Rajasthan. Her area of interest is Synthetic Medicinal Chemistry.

Yashumati Ratan: Obtained her M. Sc. Pharmaceutical Chemistry from Banasthali University, Rajasthan. Currently working as Assistant Professor at Banasthali University, Rajasthan. Her area of interest is Synthetic Medicinal Chemistry.

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