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Ueber Nucleinsauren

Altmann, Richard

Publication Date: 1889
Soft cover
From Jeremy Norman's historyofscience (Novato, CA, U.S.A.)

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Altmann, Richard (1852-1900). Ueber Nucleinsäuren. In Arch. Anat. Physiol., Physiol. Abtheil. (1889): 524-36. Whole number, 8vo. [369]-568pp., folding plate. 242 x 165 mm. (uncut & unopened). Original gray printed wrappers, chipped, a few tears. Light dampstain on folding plate, otherwise very good. First Edition. Garrison-Morton 713. Altmann coined the term "nucleic acid," which he introduced in his 1889 paper "Ueber Nucleinsäuren," and developed a convenient and general method for its preparation. His work on nucleic acids represents an early stage in the development of molecular biology. Altmann was a student of Johann Friedrich Miescher, who in 1869 discovered a hitherto unknown substance in the cell nucleus that he named nuclein; we now know it as DNA. Altmann worked with Miescher at Miescher's institute in Basel, called the "Vesalianum" after the great 16th-century anatomist. "At the time Miescher was performing biochemical investigations of salmon sperm, from which he had succeeded in isolating protamine, an important constituent of spermatazoa. However, Miescher fell into an error: he detected purine bases in the protamine he had isolated by the murexide reaction, no doubt caused by contamination with adhering DNA. Later, Miescher requested that [his associate] Piccard re-investigate this question. Piccard also detected purine bases in the acid extract of spermatozoa from which protamine was isolated. However, he concluded (correctly) that nuclein also contained purine bases. This confusion was not resolved until R. Altmann in 1889 separated protein (free of purine bases) from nuclein (called by him nucleic acid), containing xanthine bases (Wolf). ,/p>Portugal and Cohen, A Century of DNA, pp. 20-21. Fruton, Proteins, Enzymes, Genes, p. 400. Wolf, "Friedrich Miescher, the man who discovered DNA," (web reference). Bookseller Inventory # 38582

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Bibliographic Details

Title: Ueber Nucleinsauren

Publication Date: 1889

Binding: Original Wraps

Dust Jacket Condition: Dust Jacket Included

Edition: 1st Edition

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