Ueber die chemische Zusammensetzung der Eiterzellen IN: Hoppe-Seyler (ed) Medicinsich-chemische ... Ueber die chemische Zusammensetzung der Eiterzellen IN: Hoppe-Seyler (ed) Medicinsich-chemische ...

Ueber die chemische Zusammensetzung der Eiterzellen IN: Hoppe-Seyler (ed) Medicinsich-chemische Untersuchungen, Heft 4, 441-60

Miescher

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Discovery of DNA Miescher, Johann Friedrich (1844-95). Ueber die chemische Zusammensetzung der Eiterzellen. In Hoppe-Seyler, Felix, ed., Med.-chem. Untersuchungen (Berlin: Hirschwald, 1866-71), Heft 4: 441-60. 8vo. vi, 593pp. 3 lithographed plates. 210 x 141 mm. Cloth ca. 1871, title in gilt on spine. Booklabel of the Chemischen Institute der Universitšt Innsbruck, and their stamp and withdrawal stamp on title page. Fine copy. First Edition. One of the earliest significant contributions to the field that would eventually be called molecular biology. "Miescher's first and most important discovery was a new class of compounds rich in organic phosphorus and forming the major constituent of cell nuclei. He rightly concluded that these 'nucleins,' as he called them, were as important a center of metabolic activity as the proteins" (Dictionary of Scientific Biography). Miescher's "nuclein" (nucleoprotein) was later demonstrated to be the hereditary genetic material (DNA). He also was the first to suggest the existence of a genetic code. Miescher was the son of Johann Friedrich Miescher the elder, professor of pathological anatomy at the University of Bern; his uncle was Wilhelm His, Sr., professor of anatomy and physiology at the University of Basel and inventor of the microtome. After receiving his M.D. in 1868 Miescher began working under the physiological chemist Felix Hoppe-Seyler, who encouraged Miescher to study leucocytes (white blood cells). Miescher developed techniques for isolating the nuclei of these cells, and then subjected the purified nuclei to an alkaline extraction followed by acidification, resulting in a precipitate that Miescher called nuclein. Upon further analysis, Miescher was able to demonstrate the salt-like union of nuclein's two major components, an acid fraction and a basic fraction. He thus became the first to isolate and identify what we now know as DNA. Garrison-Morton 695. Bookseller Inventory # 42605

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Title: Ueber die chemische Zusammensetzung der ...

Binding: Soft cover

Edition: 1st Edition

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