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Vegf-Expressing Msc for Improved Angiogenesis in Regenerative Medicine

Uta Helmrich

ISBN 10: 3659351563 / ISBN 13: 9783659351563
Published by LAP Lambert Academic Publishing
New Condition: New Soft cover
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104 pages. Dimensions: 8.7in. x 5.9in. x 0.2in.Mesenchymal stem cells (MSC) are a valuable source of multipotent progenitors for regenerative medicine, but may require to be genetically modified to widen their efficacy. For example, overexpression of the angiogenic factor VEGF at controlled levels is an attractive strategy to overcome the crucial bottleneck of graft vascularization and to avoid aberrant vascular growth. Since the regenerative potential of MSC is rapidly lost during in vitro expansion, we developed an optimized technique to achieve high-efficiency retroviral vector transduction of both adipose tissue- and bone marrow-derived MSC (ASCBMSC) and rapidly select cells expressing desired levels of VEGF with minimal expansion. This platform was then used for various regenerative medicine approaches. The area of application described in this book covers the generation of vascularized osteogenic grafts. The presented data suggests that, even though VEGF over-expression is effective to improve angiogenesis, it has the potential to disrupt bone homeostasis towards excessive degradation. This book is useful to professionals interested in controlled expression of secreted factors, regenerative medicine and bone homeostasis. This item ships from multiple locations. Your book may arrive from Roseburg,OR, La Vergne,TN. Bookseller Inventory # 9783659351563

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Bibliographic Details

Title: Vegf-Expressing Msc for Improved ...

Publisher: LAP Lambert Academic Publishing

Binding: Paperback

Book Condition:New

Book Type: Paperback

About this title

Synopsis:

Mesenchymal stem cells (MSC) are a valuable source of multipotent progenitors for regenerative medicine, but may require to be genetically modified to widen their efficacy. For example, overexpression of the angiogenic factor VEGF at controlled levels is an attractive strategy to overcome the crucial bottleneck of graft vascularization and to avoid aberrant vascular growth. Since the regenerative potential of MSC is rapidly lost during in vitro expansion, we developed an optimized technique to achieve high-efficiency retroviral vector transduction of both adipose tissue- and bone marrow-derived MSC (ASC/BMSC) and rapidly select cells expressing desired levels of VEGF with minimal expansion. This platform was then used for various regenerative medicine approaches. The area of application described in this book covers the generation of vascularized osteogenic grafts. The presented data suggests that, even though VEGF over-expression is effective to improve angiogenesis, it has the potential to disrupt bone homeostasis towards excessive degradation. This book is useful to professionals interested in controlled expression of secreted factors, regenerative medicine and bone homeostasis.

About the Author:

Uta Helmrich, PhD: Studied Biology at the Eberhard Karls Universität Tübingen (diploma thesis at the LGN (CNRS) in Paris). PhD studies in Medical Biology at the Institute for Surgical Research and Hospital Management at the University of Basel. Currently, Research Scientist at the Osteoarthritis Research Center at the University Hospital Basel.

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