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Marina Zafranskaya, Aleksandr Fedulov, Dar'ya Nizhegorodova

Published by LAP LAMBERT Academic Publishing (2012)

ISBN 10: 3659270342 ISBN 13: 9783659270345

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Softcover

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From: Ergodebooks (RICHMOND, TX, U.S.A.)

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About this Item: LAP LAMBERT Academic Publishing, 2012. Paperback. Condition: Used: Good. Seller Inventory # SONG3659270342

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Zafranskaya Marina, Fedulov Aleksandr, Nizhegorodova Dar'ya

Published by LAP Lambert Academic Publishing, United States (2012)

ISBN 10: 3659270342 ISBN 13: 9783659270345

Softcover
New

Quantity Available: 10

From: The Book Depository EURO (London, United Kingdom)

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About this Item: LAP Lambert Academic Publishing, United States, 2012. Paperback. Condition: New. Aufl. Language: Russian. Brand new Book. V dannoy knige rassmotreny immunoregulyatornye svoystva i mekhanizmy immmunosupressii mezenkhimal'nykh stvolovykh kletok (MSK) pri autoimmunnykh demieliniziruyushchikh zabolevaniyakh tsentral'noy nervnoy sistemy cheloveka i laboratornykh zhivotnykh. Pokazano, chto autologichnye i allogennye MSK rannikh passazhey v ravnoy stepeni ingibiruyut kak antigen-nespetsificheskuyu, tak i mielin-indutsirovannuyu proliferatsiyu T-kletok pamyati patsientov s rasseyannym sklerozom. Mekhanizm MSK-indutsiruemoy immunosupressii mozhet byt' svyazan s ostanovkoy kletochnogo deleniya na urovne rannikh generatsiy, snizheniem produktsii interferona-? i povysheniem ekspressii FoxP3. Pri etom, rastvorimyy posrednik immunoregulyatornykh svoystv MSK - prostaglandin E2 konstitutivno imi ne produtsiruetsya, a trebuet parakrinnogo signala ot T-limfotsitov. Poluchennye rezul'taty pozvolyat otsenit' vozmozhnosti dal'neyshego ispol'zovaniya kul'tur MSK v kachestve kletochnogo transplantata pri patogeneticheskoy terapii rasseyannogo skleroza, usovershenstvovat' kriterii otbora patsientov i povysit' uroven' klinicheskikh i nauchnykh issledovaniy v nevrologii, immunologii, transplantologii i kletochnoy biologii. Seller Inventory # AAV9783659270345

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