Analysis and Purification Methods in Combinatorial Chemistry (Hardcover)

Bing Yan

ISBN 10: 0471269298 / ISBN 13: 9780471269298

Published by John Wiley & Sons Inc, New York, 2004

Hardcover. Quality measurement, control, and improvement in combinatorial chemistry Combinatorial chemistry has developed rapidly in the past decade, with great advances made by scientists working on analysis and purification of a large number of compounds and the analysis of polymer-bound compounds. However, formidable challenges lie ahead of today's researcher. For example, high-throughput analysis and purification technologies must be further developed to ensure combinatorial libraries are "purifiable," and "drugable." To this end, Analysis and Purification Methods in Combinatorial Chemistry describes various analytical techniques and systems for the development, validation, quality control, purification, and physicochemical testing of combinatorial libraries. A new volume in Wiley's Chemical Analysis series, this text has four parts covering: * Various approaches to monitoring reactions on solid support and optimizing reactions for library synthesis * High-throughput analytical methods used to analyze the quality of libraries * High-throughput purification techniques * Analytical methods applied in post-synthesis and post-purification stages Drawing from the contributions of respected experts in combinatorial chemistry, this comprehensive book provides coverage of applications of Nuclear Magnetic Resonance (NMR), liquid chromatography/mass spectrometry (LC/MS), Fourier Transform Infrared (FTIR), micellar electrokinetic chromatography (MEKC) technologies, as well as other analytical techniques. This eminently useful volume is an essential addition to the library of students and researchers studying or working in analytical chemistry, combinatorial chemistry, medicinal chemistry, organic chemistry, biotechnology, biochemistry, or biophysics. Describes various analytical techniques and systems for the development, validation, quality control, purification, and physicochemical testing of combinatorial libraries. This book provides coverage of applications of Nuclear Magnetic Resonance (NMR), liquid chromatography/mass spectrometry (LC/MS), and Fourier Transform Infrared (FTIR). Shipping may be from multiple locations in the US or from the UK, depending on stock availability. Seller Inventory # 9780471269298

Synopsis:

Quality measurement, control, and improvement in combinatorial chemistry
Combinatorial chemistry has developed rapidly in the past decade, with great advances made by scientists working on analysis and purification of a large number of compounds and the analysis of polymer-bound compounds. However, formidable challenges lie ahead of today's researcher. For example, high-throughput analysis and purification technologies must be further developed to ensure combinatorial libraries are "purifiable," and "drugable."
To this end, Analysis and Purification Methods in Combinatorial Chemistry describes various analytical techniques and systems for the development, validation, quality control, purification, and physicochemical testing of combinatorial libraries. A new volume in Wiley's Chemical Analysis series, this text has four parts covering:
* Various approaches to monitoring reactions on solid support and optimizing reactions for library synthesis
* High-throughput analytical methods used to analyze the quality of libraries
* High-throughput purification techniques
* Analytical methods applied in post-synthesis and post-purification stages
Drawing from the contributions of respected experts in combinatorial chemistry, this comprehensive book provides coverage of applications of Nuclear Magnetic Resonance (NMR), liquid chromatography/mass spectrometry (LC/MS), Fourier Transform Infrared (FTIR), micellar electrokinetic chromatography (MEKC) technologies, as well as other analytical techniques.
This eminently useful volume is an essential addition to the library of students and researchers studying or working in analytical chemistry, combinatorial chemistry, medicinal chemistry, organic chemistry, biotechnology, biochemistry, or biophysics.

About the Author: BING YAN, PhD, was born in China and received his PhD in chemistry at Columbia University in 1990. He then worked at Cambridge University and the University of Texas-Houston Medical School as a postdoctoral fellow. From 1993 to 1999, he worked for Novartis in the Core Technologies area of preclinical research in New Jersey. He is currently at the Discovery Chemistry division of Discovery Partners International, Inc., in San Francisco. His major research interests are drug discovery, optimization of solid-phase and solution-phase combinatorial synthesis, high-throughput quantitative and qualitative analysis, and high-throughput purification of combinatorial libraries. He has written four books and published over seventy reviews and research articles.

Bibliographic Details

Title: Analysis and Purification Methods in ...
Publisher: John Wiley & Sons Inc, New York
Publication Date: 2004
Binding: Hardcover
Condition: new
Edition: 1st Edition