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SKIN GRAFTS. First edition of this very important work on transplantation and experimental surgery in animals. "The publication of Degli Innesti Animali (On grafting in Animals) by Giuseppe Baronio (1759-1811) in 1804, the first account of experimental autologous skin transplantation in a ram, marks the beginning of a new era for plastic surgery - the demonstration that skin transfer in the same individual is possible and successful" (Mazzola). His early skin grafts on sheep are among the first closely controlled medical experiments using animals, and according to Garrison-Morton "He successfully carried out full-thickness skin grafts after detachment from the body, and the first purely scientific research in the history of plastic surgery." Baronio laid the foundation for human skin grafting, which was only successfully done for the first time 13 years later, in 1817. There are chapters on the Indian method for restoration of the nose, and the revival of this method by Carpue, on the surgery of Tagliacozzi, on teeth graft in man, and on skin grafts in animals. "It is a landmark in the development of plastic surgery procedure after two centuries of neglect" (Hagstromer Library). "It was Giuseppe Baronio, physician and naturalist of Milan, who first demonstrated on sheep that full-thickness skin grafts could be successfully transplanted after detachment from the body. In three experiments which he describes in 1804, Baronio removed from the back of a sheep patches of skin which he transplanted to new sites on the same sheep, one immediately, a second after eighteen minutes, and a third after one hour of detachment. All became successfully adherent to the new bed . . . Baronio's significant findings went unnoticed, . . . and it was not until more than fifty years later that free whole-thickness skin grafts came into general use . The basic principle of free transplantation . . . constituted, when fully understood and applied, the greatest single advance [in plastic surgery] of the nineteenth century" (Gnudi & Webster, p 328). "Baronio carried out trials on a total of 27 animals (rams, goats, dogs, and even a mare and a cow), always with the same positive results. These studies were of immense significance, serving first and foremost to demonstrate that grafts could be transferred and survive, a fact up to then had not been scientifically proven. Indeed, this possibility was dismissed by leading surgeons including Alfred Armand Velpeau who. asserted that "this strange operation will never be practiced" Furthermore, by comparing the results of grafts carried out under different conditions and different time intervals, Baronio succeeded in clarifying many of the biological aspects of the grafting and healing processes" (Santoni-Rugiu & Sykes, p. 123). Rare in such fine condition. "Degli Innesti Animali, the most important work of Baronio, is a 78-page book, printed on thick paper, issued in 1804 in Milan by Tipografia del Genio. The book is rare and seldom appears on the market. It is divided into seven parts and includes three engraved illustrations. The first one shows the portrait of the Count Carlo Anguissola, to whom the work is dedicated, who sponsored the publication, although this is not mentioned, and provided animals and stables for making Baronio's experiments possible. "In parts one and two, Baronio traces the origin of nasal reconstruction by quoting the Brancas of Sicily, Tagliacozzi, and the Maratha surgeons from India. Tagliacozzi's arm flap technique is extensively described, whereas the Indian forehead flap procedure is also illustrated by an engraved plate. Part three is devoted to transplantation of teeth in human beings, a procedure first reported by John Hunter; whereas part four explains the grafting of spur and "other animal parts into the cock's comb." In part five, Baronio reports the method of healing severed skin parts by using certain balms, as proposed by some charlatans. Part six, the most important s.
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