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The genesis of asymptomatic bacteriuria Escherichia coli strains: Evolution, bacterial genome plasticity and host-pathogen adaptations of asymptomatic bacteriuria (ABU) Escherichia coli strains

Jaroslaw Zdziarski

ISBN 10: 3639320573 / ISBN 13: 9783639320572
Published by VDM Verlag Dr. Müller, 2011
Condition: Good Soft cover
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Bibliographic Details

Title: The genesis of asymptomatic bacteriuria ...

Publisher: VDM Verlag Dr. Müller

Publication Date: 2011

Binding: Paperback

Book Condition: Good

About this title

Synopsis:

Humans are home to so much wildlife, e.g. bacteria, which outnumber our cells by as many as 10 to 1. Here I discussed the evolution of asymptomatic bacteriuria (ABU), meaning colonization of the urinary tract without typical symptoms of a urinary tract infection (UTI). ABU isolates turned out to have remarkable genetic flexibility and often have no common progenitor. Reductive evolution by point mutations, DNA rearrangements and deletions resulted in inactivation of genes coding for several UTI-virulence factors. This supports the idea that a reduced bacterial activation of host mucosal inflammation promotes the ABU lifestyle, where gene regulation and genetic diversity enable bacteria to live and survive under continuously changing environmental conditions. I could demonstrate it here by employing human colonisation study, in which E. coli was exposed to different host backgrounds and adapt its colonisation strategy. This suggested that exposure of bacteria to the human immune response promotes genome plasticity thus being a driving force for the development of ABU and bacterial evolution within the urinary tract.

About the Author:

Dr. Jaroslaw Zdziarski studied Biotechnology in Poland. In 2004, he joined The Graduate School of Live Sciences in Wrzburg. After completing PhD, he continued research at the University of Wrzburg working on bacterial genome dynamics and host-bacterium co-evolution. In 2010, he joined Biotech Company to develop techniques for pathogen detection.

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