De l'anaphylaxie ou sensibilite croissante des organismes. 33pp., 4to. Autograph manuscript signed

Richet, Charles

Published by Paris, 1911
Hardcover
From Jeremy Norman's historyofscience (Novato, CA, U.S.A.)

AbeBooks Seller Since January 9, 1999 Seller Rating 2-star rating

Association Member: ABAA

Quantity Available: 1

Buy Used
Price: US$ 5,000.00 Convert Currency
Shipping: US$ 7.50 Within U.S.A. Destination, rates & speeds
Add to basket

30 Day Return Policy

About this Item

33-Page Autograph Manuscript on Anaphylaxis by Nobel Prize Winning Immunologist Richet, Charles (1850-1935). De l'anaphylaxie ou sensibilite croissante des organismes des doses successives de poison. Autograph manuscript signed, 33 numbered loose leaves, prepared for the printer with numerous erasures and corrections. [Paris, probably before 1911.]. 210 x 157 mm. Light horizontal crease where previously folded, minor soiling, rust-marks from paper clip on first and last leaves. Very good. Preserved in a cloth folder. Richet, together with his colleague Paul Portier, discovered the phenomenon of anaphylaxis in 1902, while researching the toxins produced by the Portuguese man-of-war and sea anenome. In an attempt to convey immunity and determine experimentally the parameters of toxicity of these poisons, Richer and Portier injected dogs with doses too small to be dangerous. However, they discovered that second doses of the poison caused immediate death in some of their experimental animals, leading them to conclude that the poison had an effect exactly opposite to the immunizing properties of serums, vaccines, etc.--instead of reinforcing the body's resistance to a foreign substance, a sublethal dose of the poison diminished it. Richet continued his investigations on anaphylaxis, constructing a general theory of the phenomenon in 1907 (see G-M 2599), and attempting to explain the function of anaphylaxis in evolutionary terms. In 1913 he received the Nobel Prize in physiology or medicine for his discovery. Bookseller Inventory # 33314

Ask Seller a Question

Bibliographic Details

Title: De l'anaphylaxie ou sensibilite croissante ...

Publisher: Paris

Publication Date: 1911

Binding: Hardcover

Signed: Signed by Author(s)

Store Description

Visit Seller's Storefront

Association Member Members of these associations are committed to maintaining the highest standards. They vouch for the authenticity of all items offered for sale. They provide expert and detailed descriptions, disclose all significant defects and/or restorations, provide clear and accurate pricing, and operate with fairness and honesty during the purchase experience.
Terms of Sale:

Shipping charges will be applied to all orders. All items are guaranteed as described and all purchases may
be returned for any reason within two weeks of receipt. Please notify us in advance if you are making a
return.
Legal entity: Jeremy Norman & Co., Inc.
Business address: 936-B Seventh St., PMB 238, Novato, CA 94945-3000
Email address: orders@jnorman.com
Phone: 415-892-3181
Federal Tax ID Number:94-2261335
Authorized representative: Jeremy M. Norman


Shipping Terms:

Orders usually ship within 2 business days. Shipping costs are based on books weighing 2.2 LB, or 1 KG. If your book order is heavy or oversized, we may contact you to let you know extra shipping cost is required.

List this Seller's Books

Payment Methods
accepted by seller

Visa Mastercard American Express

Money Order PayPal Bank Draft Bank/Wire Transfer