Microarrays: Preparation, Microfluidics, Detection Methods, and Biological Applications (Integrated Analytical Systems)

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9780387727165: Microarrays: Preparation, Microfluidics, Detection Methods, and Biological Applications (Integrated Analytical Systems)
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Combinatorial chemistry is used to find materials that form sensor microarrays. This book discusses the fundamentals, and then proceeds to the many applications of microarrays, from measuring gene expression (DNA microarrays) to protein-protein interactions, peptide chemistry, carbodhydrate chemistry, electrochemical detection, and microfluidics.

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The area of microarrays has evolved from genomics, and has been applied to proteomics and single cell studies as well. The applications of microarrays benefit diverse fields ranging from fundamental systems biology to practical diagnostic tests. This book provides a critical analysis of the applications of microarrays in several key areas of bioanalytical research including DNA studies, peptide arrays, protein arrays, combinatorial chemistry arrays, cell-based arrays, and glycoarrays. Further progress in microarrays is being spurred by the advances in micro- and nano-fabrication technologies, modern molecular biology, and data mining. This book is designed to be a useful source of fundamental and current information for microarray research practitioners and for those who are just entering this field.

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"Microarray technology is not without its challenges and limitations ... this book highlight novel approaches that may address some of those issues and offer suggestions of new strategies on the horizon. ... I found many of the topics in the book to be interesting ... . it has a considerable amount of useful material for someone who ... is looking for a broader perspective on applications. It will also be useful to those focused on electrochemical detection and microfluidics in microarrays." (Peter Wentzell, Journal of the American Chemical Society, Vol. 131 (36), 2009)

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