Organic Synthesis: The Disconnection Approach - Hardcover

Warren, Stuart

9780471101604: Organic Synthesis: The Disconnection Approach

Hardcover

ISBN 10: 0471101605 ISBN 13: 9780471101604

Publisher: Wiley, 1983

One approach to organic synthesis is retrosynthetic analysis. With this approach a chemist will start with the structure of their target molecule and progressively cut bonds to create simpler molecules. Reversing this process gives a synthetic route to the target molecule from simpler starting materials. This “disconnection” approach to synthesis is now a fundamental part of every organic synthesis course.

Organic Synthesis: The Disconnection Approach, 2nd Edition introduces this important technique, to help students to design their own organic syntheses. There are forty chapters: those on the synthesis of given types of molecules alternate with strategy chapters in which the methods just learnt are placed in a wider context. The synthesis chapters cover many ways of making each type of molecule starting with simple aromatic and aliphatic compounds with one functional group and progressing to molecules with many functional groups. The strategy chapters cover questions of selectivity, protection, stereochemistry, and develop more advanced thinking via reagents specifically designed for difficult problems.

Examples are drawn from pharmaceuticals, agrochemicals, natural products, pheromones, perfumery and flavouring compounds, dyestuffs, monomers, and intermediates used in more advanced synthetic work. Reasons for wishing to synthesise each compound are given.

This second edition has been fully revised and updated with a modern look. Recent examples and techniques are included and illustrated additional material has been added to take the student to the level required by the sequel, “Organic Synthesis: Strategy and Control”.

Several chapters contain extensive new material based on courses that the authors give to chemists in the pharmaceutical industry.

Organic Synthesis: The Disconnection Approach, 2nd edition provides a full course in retrosynthetic analysis for chemistry and biochemistry students and a refresher for organic chemists working in industry and academia.

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From the Publisher:

A workbook providing additional examples, problems, and solutions for use with Warren's Organic Synthesis: The Disconnection Approach. Exercises correspond to chapters in the main text. Problems of special ease or difficulty are labeled for optional use. Workbook includes a formula index of all target molecules contained in the text and workbook.

From the Back Cover:

"Organic Synthesis: Strategy and Control" is a sequel to Stuart Warren's bestseller "Organic Synthesis: The Disconnection Approach," The 'Disconnection' book concentrated on the planning behind the synthesis of compounds.

The two themes of this new book are "strategy" and "control: " solving problems either by finding an alternative strategy or by controlling any established strategy to make it work.

The book is divided into five sections that deal with selectivity, carbon-carbon single bonds, carbon-carbon double bonds, stereochemistry and functional group strategy. Interpenetrating this structure, the 36 chapters start with classic methods and progress to modern methods and modern strategic considerations. Heterocyclic chemistry is treated throughout the book with full mechanistic explanations as part of organic chemistry rather than a separate mystery.

A comprehensive, practical account of the key concepts involved in synthesising compounds. Takes a mechanistic approach, which explains reactions and gives guidelines on how reactions might behave in different situations. Focuses on reactions that really work rather than those with limited application. Extensive, up-to-date references in each chapter.

Students and professional chemists familiar with "Organic Synthesis: The Disconnection Approach" will enjoy the leap into a book designed for chemists at the coalface of organic synthesis.

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