Etiology of Breast and Gynecological Cancers (Progress in Clinical and Biological Research) - Hardcover

Hardcover

ISBN 10: 0471169013 ISBN 13: 9780471169017

Publisher: Wiley-Liss, 1997

Synopsis

Progress in Clinical and Biological Research, Volume 396 Etiology of Breast and Gynecological Cancers Proceedings of the Ninth International Conference on Carcinogenesis and Risk Assessment, Held in Austin, Texas, November 29-December 2, 1995 C. Marcelo Aldaz, Michael N. Gould, John McLachlan, and Thomas J. Slaga, Editors Accounting for 150 cancers per 100,000 people at risk, breast cancer and gynecological cancer together constitute a major public health concern. These cancers have a common target population, and many also have common etiological features, including hormonal factors, genetic changes in genes such as BRCA1, and environmental factors such as ionizing radiation, viruses, chemical xenobiotics, diet, and nutrition. Etiology of Breast and Gynecological Cancers explores important environmental and genetic factors that are key to the induction of these cancers. The book takes a broad perspective, with chapters contributed by laboratory investigators and clinicians, as well as by epidemiologists. It emphasizes validation and issues of extrapolation from animal models to humans and their impact on risk assessment, and it also discusses intervention strategies in terms of chemoprevention, which has the potential to reduce the morbidity and mortality from these cancers in women. Etiology of Breast and Gynecological Cancers explores a wide variety of topics, including:
* recent advances in the molecular genetics of hereditary breast and ovarian cancer
* molecular perspectives on cancer, the cell cycle, and the inherited disorder ataxia-telangiectasia
* genotoxicity of environmental agents in human mammary epithelial cells
* rodent model of reproductive tract leiomyomata
* estrogens and the genetic control of tumor growth
Featuring 19 outstanding presentations from leading researchers in an array of disciplines, Etiology of Breast and Gynecological Cancers is an important resource for investigators and clinicians in oncology, epidemiology, and public health, providing new understanding of the sources of these disorders as well as new directions for treatment and prevention.

About this title

From the Publisher:

Despite recent advances in research and prevention, the incidence of common female cancers is still increasing. This book reviews the most recent advances in the fields of breast and gynecological carcinogenesis. It discusses the validity of animal models for study of these human diseases and addresses the relative contributions of genetic predisposition and environmental exposure to potential carcinogens including environmental hormone disrupters. Reviews the most recent advances in the field of breast and gynecological cancers. Discusses environmental influences that play a role in hormone-mediated neoplasias.

About this edition

• Publisher: Wiley-Liss
• Publication date: 1997
• ISBN 10: 0471169013
• ISBN 13: 9780471169017
• Binding: Hardcover
• Edition number: 1
• Number of pages: 296
• Editor: Aldaz C. Marcelo, Gould Michael N., McLachlan J. C., Slaga Thomas J.