On the cover of this book is a Pacific yew tree, found in the ancient forests of the Pacific Northwest. The bark of the Pacific yew tree produces Taxol, found to be a highly effective drug against ovarian and breast cancer. Taxol blocks mitosis during eukaryotic cell division. The supply of Taxol from the Pacific yew tree is vanishingly small, however. A single 100-year-old tree provides only about one dose of the drug (roughly 300 mg). For this reason, as well as the spectacular molecular architecture of Taxol, synthetic organic chemists fiercely undertook efforts to synthesize it. Five total syntheses of Taxol have thus far been reported. Now, a combination of isolation of a related metabolite from European yew needles, and synthesis of Taxol from that intermediate, supply the clinical demand. This case clearly demonstrates the importance of synthesis and the use of organic chemistry. It's just one of the many examples used in the text that will spark the interest of students and get them involved in the study of organic chemistry!
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This revised edition presents reaction mechanisms in the context of real functional group chemistry and emphasizes the biological, environmental and medical applications of organic chemistry. The new edition maintains the same quality and approach that made prior editions so popular. Includes detailed explanations of mechanisms, structure and theory with careful attention given to the use of curved arrows. Features many more examples of organic acid-base reactions and an extended discussion of aromatic compounds.About the Author:
Graham Solomons, University of South Florida
Craig Fryhle, Pacific Lutheran University
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Book Description Wiley, 1999. Hardcover. Book Condition: New. Bookseller Inventory # P110471190950
Book Description Wiley. Hardcover. Book Condition: New. 0471190950 New Condition. Bookseller Inventory # NEW6.0246192
Book Description Wiley, 1999. Hardcover. Book Condition: New. 7th. Bookseller Inventory # DADAX0471190950
Book Description John Wiley & Sons. Book Condition: New. pp. 1344. Bookseller Inventory # 3186880