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Drug Discovery and Evaluation

ISBN 13: 9783540423966

Drug Discovery and Evaluation

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9783540423966: Drug Discovery and Evaluation
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Now expanded and updated to include molecular biology and genetic engineering techniques! The 2nd edition of this successful reference book contains a comprehensive selection of the most frequently used assays for reliably detecting the pharmacological effects of potential drugs. Effects covered include cardiovascular, analgesic, endocrine, psychotropic respiratory, renal and immunomodulatory activities. Each of the more than 1000 assays comprises a detailed protocol outlining the purpose and rationale of the method, a critical assessment of the results and their pharmacological and clinical relevance. The enclosed and fully searchable CD-ROM allows easy identification of specific tests. An appendix with up-to-date guidelines and legal regulations for animal experiments in various countries will help the reader to plan experiments more effectively.

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About the Author:

H. Gerhard Vogel is a licenced Pharmacist and Physician (Universities of Erlangen and Tübingen, Germany). He taught as Professor of Pharmacology and Toxicology at the Universities Marburg and Frankfurt. He joined Research at the pharmaceutical company Hoechst AG, Frankfurt, to become Head of Endocrinology, Head of the Department of Pharmacology, and the Head of International Preclinical Evaluation and Development. His latest position was Head of the Decision Board on Pharmaceutical Development. At present, he is working as a Consultant for Pharmaceutical and Medical Research and Development. His scientific work was devoted to the elaboration of new pharmacological methods, pharmacology of plant extracts from various countries, pharmacology of steroid hormones, pharmacology of peptide hormones, pharmacology of cardiac glycosides, biomechanics and biochemistry of connective tissue, experimental gerontology, experimental dermatology, and development procedures for pharmaceutical products. H. Gerhard Vogel has published more than 160 papers, mainly on new pharmacological methods, on endocrinology (in particular peptide endocrinology), biomechanics and biochemistry of connective tissue, such as skin and bone, and on other topics. He is a member of many international and national scientific societies and a co-editor and contributor to several scientific textbooks. Together with Wolfgang H. Vogel he published the first edition of Drug Discovery and Evaluation: Pharmacological Assays (Springer-Verlag Berlin Heidelberg New York) in 1997. The second completely revised, updated and enlarged edition with many contributions by his colleagues was published in 2002. The third edition of that work will appear in late 2007. He is also Editor-in-Chief of the book Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays, which was published at Springer as well.

Review:

From the reviews of the second edition:

"Pharmacological studies are a pivotal but sometimes neglected area ... . Failure to evaluate your candidate compound in appropriate models will greatly reduce your chances of success ... . This excellent reference book will assist you in avoiding this fate. ... Although the update has increased the book from around 750 to 1400 pages, it is still indexed in a clear, concise way making access to each assay easy. ... I would thoroughly recommend this book. ... it is a well-worth, long term investment." (Paul Baldrick, British Toxicology Society Newsletter, Issue 20, 2002)

"The second edition of ‘Drug Discovery and Evaluation’ presents an expanded and updated version of one of the classic reference handbooks on pharmacological assays. ... Each assay description is sufficiently outlined and equipped with outstanding literature references. ... A newly included CD-ROM provides easy identification of tests, guidelines and even legal regulations for animal experiments. ... This comprehensive classical reference handbook mainly addresses the needs of pharmacological institutes and research groups working in this area." (Dr. Jürg Gertsch, BioWorld, Issue 2, 2003)

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