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Book Description Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The purpose of this investigation was to design and develop gastroretentive dosage form for levofloxacin hemihydrate using floating tablet approach with various grades of hydroxypropyl methyl cellulose. Levofloxacin highly soluble in acidic media and precipitates in alkaline media thereby losing its solubility. Hence, a gastro retentive system was developed to enhance the bioavailability and therapeutic efficacy by retaining them in the acidic environment of the stomach. Sodium bicarbonate was used in the dosage form as a source of carbon-di-oxide to maintain buoyancy. In vitro dissolution study results indicated non-Fickian diffusion controlled drug release mechanism and was best fitted into zero-order equation. In vivo radiographic studies conducted in healthy human volunteers for optimized formulation indicated over 5 h retention of tablet in the stomach region. Reproducible physical parameters indicated that the current formulation could be easily scaled-up. 64 pp. Englisch. Seller Inventory # 9783659238147
Book Description Condition: New. New! This book is in the same immaculate condition as when it was published. Seller Inventory # 353-3659238147-new
Book Description Condition: New. Buy with confidence! Book is in new, never-used condition. Seller Inventory # bk3659238147xvz189zvxnew
Book Description Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - The purpose of this investigation was to design and develop gastroretentive dosage form for levofloxacin hemihydrate using floating tablet approach with various grades of hydroxypropyl methyl cellulose. Levofloxacin highly soluble in acidic media and precipitates in alkaline media thereby losing its solubility. Hence, a gastro retentive system was developed to enhance the bioavailability and therapeutic efficacy by retaining them in the acidic environment of the stomach. Sodium bicarbonate was used in the dosage form as a source of carbon-di-oxide to maintain buoyancy. In vitro dissolution study results indicated non-Fickian diffusion controlled drug release mechanism and was best fitted into zero-order equation. In vivo radiographic studies conducted in healthy human volunteers for optimized formulation indicated over 5 h retention of tablet in the stomach region. Reproducible physical parameters indicated that the current formulation could be easily scaled-up. Seller Inventory # 9783659238147
Book Description Kartoniert / Broschiert. Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Dudhipala NarendarMr. Narendar Reddy Dudhipala, presently Research Scholar under the supervision of Prof. V. Kishan in the Department of Pharmaceutics at University College of Pharmaceutical Sciences, Kakatiya University, Warangal, A. Seller Inventory # 5142104
Book Description Paperback. Condition: Brand New. 64 pages. 8.82x6.18x0.39 inches. In Stock. Seller Inventory # zk3659238147