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Molecular Modeling Studies of TLRs: Comparative Modeling and Functional Analysis of Toll-Like Receptors Ligand-Recognition Domains - Softcover
Toll-like receptors (TLRs) play a central role in bridging the innate and adaptive immune responses. TLR signaling pathways are also implicated in serious autoimmune diseases such as endotoxic shock and thus are important therapeutic targets. Owing to the lack of TLR structural information, explanations for ligand-binding mechanisms have been difficult to provide. Computational modeling enables initial predictions of three-dimensional structures for the investigation of receptor-ligand interaction mechanisms. In order to understand the nature of the interactions of the TLR ECD with their ligands, we constructed three dimensional structures of human TLR10, human TLR8, mouse TLR8, rat TLR8, bovine TLR8 and porcine TLR8 and refined the model through molecular dynamics (MD) simulations. Subsequently, models of essential complexes involved in the TLR signaling processes were yielded through protein-protein docking analysis. The observed functional studies and their implication for ligand recognition by TLRs could lead to the development of adjuvants that specifically bind to the TLR ECD and activate the TLRs or anti-inflammatory drugs that block TLR mediated signaling.
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Dr.Rajiv Gandhi, Ph.D. Post-doctoral Fellow in Computational biology at KAIST (Korea Advanced Institute of Science and Technology), Daejeon, South Korea.Field of study : Protein Structure and Functional analysis.Main Subject : Computational biology
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- PublisherLAP LAMBERT Academic Publishing
- Publication date2013
- ISBN 10 3659337455
- ISBN 13 9783659337451
- BindingPaperback
- Number of pages80
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Molecular Modeling Studies of Tlrs
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Molecular Modeling Studies of TLRs: Comparative Modeling and Functional Analysis of Toll-Like Receptors Ligand-Recognition Domains
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Molecular Modeling Studies of TLRs Comparative Modeling and Functional Analysis of TollLike Receptors LigandRecognition Domains
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Molecular Modeling Studies of TLRs
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Book Description Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Toll-like receptors (TLRs) play a central role in bridging the innate and adaptive immune responses. TLR signaling pathways are also implicated in serious autoimmune diseases such as endotoxic shock and thus are important therapeutic targets. Owing to the lack of TLR structural information, explanations for ligand-binding mechanisms have been difficult to provide. Computational modeling enables initial predictions of three-dimensional structures for the investigation of receptor-ligand interaction mechanisms. In order to understand the nature of the interactions of the TLR ECD with their ligands, we constructed three dimensional structures of human TLR10, human TLR8, mouse TLR8, rat TLR8, bovine TLR8 and porcine TLR8 and refined the model through molecular dynamics (MD) simulations. Subsequently, models of essential complexes involved in the TLR signaling processes were yielded through protein-protein docking analysis. The observed functional studies and their implication for ligand recognition by TLRs could lead to the development of adjuvants that specifically bind to the TLR ECD and activate the TLRs or anti-inflammatory drugs that block TLR mediated signaling. 80 pp. Englisch. Seller Inventory # 9783659337451
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Molecular Modeling Studies of TLRs Comparative Modeling and Functional Analysis of TollLike Receptors LigandRecognition Domains
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Molecular Modeling Studies of TLRs : Comparative Modeling and Functional Analysis of Toll-Like Receptors Ligand-Recognition Domains
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Book Description Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Toll-like receptors (TLRs) play a central role in bridging the innate and adaptive immune responses. TLR signaling pathways are also implicated in serious autoimmune diseases such as endotoxic shock and thus are important therapeutic targets. Owing to the lack of TLR structural information, explanations for ligand-binding mechanisms have been difficult to provide. Computational modeling enables initial predictions of three-dimensional structures for the investigation of receptor-ligand interaction mechanisms. In order to understand the nature of the interactions of the TLR ECD with their ligands, we constructed three dimensional structures of human TLR10, human TLR8, mouse TLR8, rat TLR8, bovine TLR8 and porcine TLR8 and refined the model through molecular dynamics (MD) simulations. Subsequently, models of essential complexes involved in the TLR signaling processes were yielded through protein-protein docking analysis. The observed functional studies and their implication for ligand recognition by TLRs could lead to the development of adjuvants that specifically bind to the TLR ECD and activate the TLRs or anti-inflammatory drugs that block TLR mediated signaling. Seller Inventory # 9783659337451
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Molecular Modeling Studies of TLRs
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Book Description Kartoniert / Broschiert. Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Govindaraj Rajiv GandhiDr.Rajiv Gandhi, Ph.D. Post-doctoral Fellow in Computational biology at KAIST (Korea Advanced Institute of Science and Technology), Daejeon, South Korea.Field of study : Protein Structure and Functional analysi. Seller Inventory # 5149488
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