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The main problem associated with Neospora caninum and the corresponding disease, neosporosis, are abortions in cattle causing serious veterinary health issues and economic losses within livestock production. In the work presented here, the efficacy of toltrazuril, an anti-coccidial drug, was further investigated using two approaches: (I) a mouse model to assess the effect of the drug on congenitally acquired N. caninum-infection in newborn mice and (II) cell culture-based assays to assess treatment duration time for parasitostatic versus parasiticidal activity. Furthermore, the work was directed to establish a novel molecular detection method to clearly distinguish between live and dead parasites. The last part of the thesis work concentrated on the immune response induced by N. caninum. To pursue this, interaction of N. caninum with dendritic cells (DCs) was examined, as nothing is known so far about the invasion ability of N. caninum into DCs and the survival of parasites in these cells.
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About the Author:
Maria Strohbusch did her study in Biochemistry at the Friedrich- Schiller Univeristy Jena (Germany) from 2000 to 2005. After her diploma work, she swtiched to the Institute for Parasitology of Vetsuisse- and Medical Faculty Bern (Switzerland)and did her PhD work within the Graduate School for Cellular and Biomedical Sciences in Bern.
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- PublisherSuedwestdeutscher Verlag fuer Hochschulschriften
- Publication date2009
- ISBN 10 3838112687
- ISBN 13 9783838112688
- BindingPaperback
- Number of pages128
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Book Description Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The main problem associated with Neospora caninum and the corresponding disease, neosporosis, are abortions in cattle causing serious veterinary health issues and economic losses within livestock production. In the work presented here, the efficacy of toltrazuril, an anti-coccidial drug, was further investigated using two approaches: (I) a mouse model to assess the effect of the drug on congenitally acquired N. caninum-infection in newborn mice and (II) cell culture-based assays to assess treatment duration time for parasitostatic versus parasiticidal activity. Furthermore, the work was directed to establish a novel molecular detection method to clearly distinguish between live and dead parasites. The last part of the thesis work concentrated on the immune response induced by N. caninum. To pursue this, interaction of N. caninum with dendritic cells (DCs) was examined, as nothing is known so far about the invasion ability of N. caninum into DCs and the survival of parasites in these cells. 128 pp. Englisch. Seller Inventory # 9783838112688
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Neospora caninum Killing the Survival Artist New Treatment and Detection Approaches
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Neospora caninum: Killing the Survival Artist : New Treatment and Detection Approaches
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Book Description Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - The main problem associated with Neospora caninum and the corresponding disease, neosporosis, are abortions in cattle causing serious veterinary health issues and economic losses within livestock production. In the work presented here, the efficacy of toltrazuril, an anti-coccidial drug, was further investigated using two approaches: (I) a mouse model to assess the effect of the drug on congenitally acquired N. caninum-infection in newborn mice and (II) cell culture-based assays to assess treatment duration time for parasitostatic versus parasiticidal activity. Furthermore, the work was directed to establish a novel molecular detection method to clearly distinguish between live and dead parasites. The last part of the thesis work concentrated on the immune response induced by N. caninum. To pursue this, interaction of N. caninum with dendritic cells (DCs) was examined, as nothing is known so far about the invasion ability of N. caninum into DCs and the survival of parasites in these cells. Seller Inventory # 9783838112688
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Book Description Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. The main problem associated with Neospora caninum and the corresponding disease, neosporosis, are abortions in cattle causing serious veterinary health issues and economic losses within livestock production. In the work presented here, the efficacy of toltr. Seller Inventory # 5405645
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