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CONTROLLED RELEASE FORMULATION OF ANTIHYPERTENSIVE DRUGS: Design and Optimization of Controlled Release Formulations for Calcium Channel Blockers - Softcover
In present work an attempt has been made to improve to the therapeutic efficacy, systemic absorption of drug and patient compliance by developing extended release matrix tablet formulations of diltiazem HCl (DIL) and verapamil HCL (VER). DIL and VER matrix tablet formulations were prepared by direct compression by using various combination of HPMC K15M CR and Eudragit RSPO polymer. A full factorial design was applied to systematically optimize drug release profile. For optimization study and data analysis software OPTI – STAT was developed. The optimized formulations shows regression value for Higuchi kinetics indicated the diffusion dependence for drug release. Stability trials up to three months displayed excellent reproducibility. In vivo studies were carried out on the optimized batches and CF using new developed HPLC and LC-MS/MS methods A good correlation between the dissolution profiles and bioavailability indicated a linear relationship between in vitro – in vivo data.
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About the Author:
Dr. Dheeraj T. Baviskar, M.Pharm, Ph.D.,D.B.M., A.I.C studied Post Doctarate (2010), Ph.D. (2007) and M.Pharm (Quality Assurance, 2000). Professor and Principal at Institute of Pharmaceutical Education, Boradi,Tal- Shirpur, Dist-Dhule,(M.S.)India. Twelve years experiance at UG & PG level. Approved Supervisor for PG & Ph.D. students.
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- PublisherLAP LAMBERT Academic Publishing
- Publication date2011
- ISBN 10 3844392416
- ISBN 13 9783844392418
- BindingPaperback
- Number of pages324
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CONTROLLED RELEASE FORMULATION OF ANTIHYPERTENSIVE DRUGS: Design and Optimization of Controlled Release Formulations for Calcium Channel Blockers
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CONTROLLED RELEASE FORMULATION OF ANTIHYPERTENSIVE DRUGS
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Book Description Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In present work an attempt has been made to improve to the therapeutic efficacy, systemic absorption of drug and patient compliance by developing extended release matrix tablet formulations of diltiazem HCl (DIL) and verapamil HCL (VER). DIL and VER matrix tablet formulations were prepared by direct compression by using various combination of HPMC K15M CR and Eudragit RSPO polymer. A full factorial design was applied to systematically optimize drug release profile. For optimization study and data analysis software OPTI STAT was developed. The optimized formulations shows regression value for Higuchi kinetics indicated the diffusion dependence for drug release. Stability trials up to three months displayed excellent reproducibility. In vivo studies were carried out on the optimized batches and CF using new developed HPLC and LC-MS/MS methods A good correlation between the dissolution profiles and bioavailability indicated a linear relationship between in vitro in vivo data. 324 pp. Englisch. Seller Inventory # 9783844392418
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CONTROLLED RELEASE FORMULATION OF ANTIHYPERTENSIVE DRUGS
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Book Description Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Baviskar Dr. DheerajDr. Dheeraj T. Baviskar, M.Pharm, Ph.D.,D.B.M., A.I.C studied Post Doctarate (2010), Ph.D. (2007) and M.Pharm (Quality Assurance, 2000). Professor and Principal at Institute of Pharmaceutical Education, Boradi,. Seller Inventory # 5476727
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CONTROLLED RELEASE FORMULATION OF ANTIHYPERTENSIVE DRUGS : Design and Optimization of Controlled Release Formulations for Calcium Channel Blockers
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ISBN 13: 9783844392418
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Book Description Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - In present work an attempt has been made to improve to the therapeutic efficacy, systemic absorption of drug and patient compliance by developing extended release matrix tablet formulations of diltiazem HCl (DIL) and verapamil HCL (VER). DIL and VER matrix tablet formulations were prepared by direct compression by using various combination of HPMC K15M CR and Eudragit RSPO polymer. A full factorial design was applied to systematically optimize drug release profile. For optimization study and data analysis software OPTI STAT was developed. The optimized formulations shows regression value for Higuchi kinetics indicated the diffusion dependence for drug release. Stability trials up to three months displayed excellent reproducibility. In vivo studies were carried out on the optimized batches and CF using new developed HPLC and LC-MS/MS methods A good correlation between the dissolution profiles and bioavailability indicated a linear relationship between in vitro in vivo data. Seller Inventory # 9783844392418
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CONTROLLED RELEASE FORMULATION OF ANTIHYPERTENSIVE DRUGS Design and Optimization of Controlled Release Formulations for Calcium Channel Blockers
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(2011)
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ISBN 13: 9783844392418
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CONTROLLED RELEASE FORMULATION OF ANTIHYPERTENSIVE DRUGS Design and Optimization of Controlled Release Formulations for Calcium Channel Blockers
Published by
LAP LAMBERT Academic Publishing
(2011)
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ISBN 13: 9783844392418
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