DNA Topoisomerases: Topoisomerase-Targeting Drugs (Volume 29B) (Advances in Pharmacology, Volume 29B) - Hardcover
Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular basis of drug action, both applied and experimental.
"synopsis" may belong to another edition of this title.
From the Back Cover:
Praise for the Serial
"The book provides superb reading material which chemists and pharmacologists interested in the area of chemotherapy will surely enjoy reading."
--JOURNAL OF PHARMACEUTICAL SCIENCES
During the past 50 years, many chemicals of either synthetic or natural origin have been successfully used in the treatment of cancer. Most, if not all, of these drugs were developed empirically based on their antitumor activities in vitro and in vivo. Studies of topoisomerases as antitumor drug targets have been particularly intensive over the past decade. This is in part due to the recent identification of topoisomerases as the molecular targets for many antitumor drugs. New and improved therapies for cancer are being developed through studies of these novel drugs.
This book will be a long-lasting reference for students and researchers of pharmacology, toxicology, molecular biology, oncology, and infectious diseases.
LEROY F. LIU serves as the Chair and Professor in the Department of Pharmacology at the Robert Wood Johnson Medical School in Piscataway, New Jersey. Dr. Liu earned his B.S. in Chemistry at the National Taiwan University in 1971. He attended the University of California, Berkeley, and received his doctorate in Biophysical Chemistry in 1977. Liu has also held various teaching positions, including Visiting Professor at Academic Sinica in Taiwan and both Assistant and Associate Professor at the Johns Hopkins University School of Medicine.
A Searle Scholar (1981-1984), Liu was awarded the American Chemical Society Faculty Research Award (1985-1990) and the George H. Hitchings Award for Innovative Drug Design in 1989. Dr. Liu's research interests include Topoisomerases in DNA structure and function, DNA damage and repair, and cancer biology and pharmacology. Along with this contribution to Advances in Pharmacology, Liu has written more than 100 scientific articles.
About the Author:
"The book provides superb reading material which chemists and pharmacologists interested in the area of chemotherapy will surely enjoy reading."
--JOURNAL OF PHARMACEUTICAL SCIENCES
During the past 50 years, many chemicals of either synthetic or natural origin have been successfully used in the treatment of cancer. Most, if not all, of these drugs were developed empirically based on their antitumor activities in vitro and in vivo. Studies of topoisomerases as antitumor drug targets have been particularly intensive over the past decade. This is in part due to the recent identification of topoisomerases as the molecular targets for many antitumor drugs. New and improved therapies for cancer are being developed through studies of these novel drugs.
This book will be a long-lasting reference for students and researchers of pharmacology, toxicology, molecular biology, oncology, and infectious diseases.
LEROY F. LIU serves as the Chair and Professor in the Department of Pharmacology at the Robert Wood Johnson Medical School in Piscataway, New Jersey. Dr. Liu earned his B.S. in Chemistry at the National Taiwan University in 1971. He attended the University of California, Berkeley, and received his doctorate in Biophysical Chemistry in 1977. Liu has also held various teaching positions, including Visiting Professor at Academic Sinica in Taiwan and both Assistant and Associate Professor at the Johns Hopkins University School of Medicine.
A Searle Scholar (1981-1984), Liu was awarded the American Chemical Society Faculty Research Award (1985-1990) and the George H. Hitchings Award for Innovative Drug Design in 1989. Dr. Liu's research interests include Topoisomerases in DNA structure and function, DNA damage and repair, and cancer biology and pharmacology. Along with this contribution to Advances in Pharmacology, Liu has written more than 100 scientific articles.
Ferid Murad was born in Whiting, Indiana. Working concurrently on an M.D. and Ph.D. in Pharmacology, Dr. Murad graduated with both degrees from Case Western Reserve University, Cleveland, Ohio, in 1965. His many honors include the Alfred S. Maschke Award for Clinical Excellence from Case Western Reserve University in 1965. He has held several distinguished positions, including Acting Chairman in the Department of Medicine and Acting Division Chief, Division of Respiratory Medicine at Stanford University. He currently is CEO and President of Molecular Geriatrics Corporation in Lake Bluff, Illinois. Dr. Murad is married and has five children.
Joseph T. Coyle, McLean Hospital, Harvard Medical School, Belmont, Massachusetts, USA
Leroy F. Liu serves as the Chair and Professor in the Department of Pharmacology at the Robert Wood Johnson Medical School in Piscataway, New Jersey. Dr. Liu earned his B.S. in Chemistry at the National Taiwan University in 1971. He attended the University of California, Berkeley, and received his doctorate in Biophysical Chemistry in 1977. Liu has also held various teaching positions, including Visiting Professor at Academic Sinica in Taiwan and both Assistant and Associate Professor at the Johns Hopkins University School of Medicine.A Searle Scholar (1981-1984), Liu was awarded the American Chemical Society Faculty Research Award (1985-1990) and the George H. Hitchings Award for Innovative Drug Design in 1989. Dr. Liu's research interests include Topoisomerases in DNA structure and function, DNA damage and repair, and cancer biology and pharmacology. Along with this contribution to Advances in Pharmacology, Liu has written more than 100 scientific articles.
Joseph T. Coyle, McLean Hospital, Harvard Medical School, Belmont, Massachusetts, USA
Leroy F. Liu serves as the Chair and Professor in the Department of Pharmacology at the Robert Wood Johnson Medical School in Piscataway, New Jersey. Dr. Liu earned his B.S. in Chemistry at the National Taiwan University in 1971. He attended the University of California, Berkeley, and received his doctorate in Biophysical Chemistry in 1977. Liu has also held various teaching positions, including Visiting Professor at Academic Sinica in Taiwan and both Assistant and Associate Professor at the Johns Hopkins University School of Medicine.A Searle Scholar (1981-1984), Liu was awarded the American Chemical Society Faculty Research Award (1985-1990) and the George H. Hitchings Award for Innovative Drug Design in 1989. Dr. Liu's research interests include Topoisomerases in DNA structure and function, DNA damage and repair, and cancer biology and pharmacology. Along with this contribution to Advances in Pharmacology, Liu has written more than 100 scientific articles.
"About this title" may belong to another edition of this title.
- PublisherAcademic Press
- Publication date1994
- ISBN 10 0120329301
- ISBN 13 9780120329304
- BindingHardcover
- Edition number1
- Number of pages315
- EditorLiu Leroy F.
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Dna Topoisomerases: Topoisomerase-Targeting Drugs (Advances in Pharmacology, Volume 29B) (Volume 29b)
Published by
Academic Press
(1994)
ISBN 10: 0120329301
ISBN 13: 9780120329304
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Hardcover
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Book Description Condition: Good. Volume 29b. This is an ex-library book and may have the usual library/used-book markings inside.This book has hardback covers. In good all round condition. Dust jacket in good condition. Please note the Image in this listing is a stock photo and may not match the covers of the actual item,750grams, ISBN:9780120329304. Seller Inventory # 9643976
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ADVANCES IN PHARMACOLOGY : Volume 29 B : DNA Topoisomerases : Targeting Drugs
Published by
Academic Press, USA
(1994)
ISBN 10: 0120329301
ISBN 13: 9780120329304
Used
Hardcover
Quantity: 1
Seller:
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Book Description Hardcover. Condition: Fine. No Jacket. 0120329301. A near fine ex lib. hardcover. Lending record shows this book has never been borrowed. 315 pages, index, illustrated with charts, tables and diagrams. Chapters include discussions on Topoisomerase Interactive Drugs; Topoisomerases in Human Leukemia; Camptothecins; Mechanisms of Topoisomerase I Inhibition by Anticancer Drugs; Drug Resistant Mechanisms of Topoisomerase I Drugs; Topoisomerase II Targeted Antineoplastic Drugs; Determinants of Sensitivity to Topoisomerase Targeting Antitumor Drugs; Resistance of Mammalian Tumor Cells to Inhibitors of DNA Topoisomerase II; Bacteriophage Model System for Studying Topoisomerase Inhibitors; Drugs Affecting Trypanosome Topoisomerases; Yeast as a Genetic Model System for Studying Topoisomerase Inhibitors; DNA Topoisomerase Inhibitors as Antifungal Agents; Design of Topoisomerase Inhibitors to Overcome MDR1 Mediated Drug resistance; DNA Supercoiling and DNA Topoisomerase Catalyzed Linking Number Changes of Supercoiled DNA; References. Contents clean, tight and bright. Book. Seller Inventory # 026496
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