Antioxidants in Disease Mechanisms and Therapy (Volume 38) (Advances in Pharmacology, Volume 38) - Hardcover

Hardcover

ISBN 10: 0120329395 ISBN 13: 9780120329397

Publisher: Academic Press, 1996

Synopsis

Antioxidants in Disease Mechanisms and Therapy presents molecular actions of natural and synthetic antioxidants and emphasizes the potential role in disease mechanisms and therapeutic strategies. The modulationof gene expression by the induction of antioxidant enzymes is a novel role beyond the direct antioxidant action. The volume explores the current state of knowledge on oxidants and antioxidants in disease processes, including arteriosclerosis, adult respiratory distress syndrome, cystic fibrosis, Down's syndrome, inflammation, cataract, age-related macular degeneration, afflications of the nervous system, AIDS, liver diseases, diabetes, skin diseases, and cancer.

• Contains cutting-edge information on focused topics written by expert scientists
• Provides the first in-depth treatment of novel compounds, such as melatonin and polyamines
• Attempts molecular pathophysiology which links basic science and the clinic
• Presents critical assessment of controversial topics

About this title

From the Back Cover:

Praise for the Series "Recommended not only to pharmacologists but also to all those in related disciplines." --NATURE

Antioxidants in Disease Mechanisms and Therapy presents molecular actions of natural and synthetic antioxidants and emphasizes the potential role in disease mechanisms and therapeutic strategies. The modulation of gene expression by the induction of antioxidant enzymes is a novel role beyond the direct antioxidant action. The volume explores the current state of knowledge on oxidants and antioxidants in disease processes, including arteriosclerosis, adult respiratory distress syndrome, cystic fibrosis, Down's syndrome, inflammation, cataract, age-related macular degeneration, afflictions of the nervous system, AIDS, liver diseases, diabetes, skin diseases, and cancer.

Key Features

• Contains cutting-edge information on focused topics written by expert scientists
• Provides the first in-depth treatment of novel compounds, such as melatonin and polyamines
• Attempts molecular pathophysiology which links basic science and the clinic
• Presents critical assessment of controversial topics

About the Author:

Ferid Murad was born in Whiting, Indiana. Working concurrently on an M.D. and Ph.D. in Pharmacology, Dr. Murad graduated with both degrees from Case Western Reserve University, Cleveland, Ohio, in 1965. His many honors include the Alfred S. Maschke Award for Clinical Excellence from Case Western Reserve University in 1965. He has held several distinguished positions, including Acting Chairman in the Department of Medicine and Acting Division Chief, Division of Respiratory Medicine at Stanford University. He currently is CEO and President of Molecular Geriatrics Corporation in Lake Bluff, Illinois. Dr. Murad is married and has five children.

Joseph T. Coyle, McLean Hospital, Harvard Medical School, Belmont, Massachusetts, USA

Lester Packer received a PhD in Microbiology and Biochemistry in 1956 from Yale University. In 1961, he joined the University of California at Berkeley serving as Professor of Cell and Molecular Biology until 2000, and then was appointed Adjunct Professor, Pharmacology and Pharmaceutical Sciences, School of Pharmacy at the University of Southern California.

Dr Packer received numerous distinctions including three honorary doctoral degrees, several distinguished Professor appointments. He was awarded Chevalier de l’Ordre National du Merite (Knight of the French National Order of Merit) and later promoted to the rank of Officier. He served as President of the Society for Free Radical Research International (SFRRI), founder and Honorary President of the Oxygen Club of California.

He has edited numerous books and published research; some of the most cited articles have become classics in the field of free radical biology:

Dr Packer is a member of many professional societies and editorial boards. His research elucidated - the Antioxidant Network concept. Exogenous lipoic acid was discovered to be one of the most potent natural antioxidants and placed as the ultimate reductant or in the pecking order of the “Antioxidant Network regenerating vitamins C and E and stimulating glutathione synthesis, thereby improving the overall cellular antioxidant defense. The Antioxidant Network is a concept addressing the cell’s redox status. He established a world-wide network of research programs by supporting and co-organizing conferences on free radical research and redox biology in Asia, Europe, and America.

About this edition

• Publisher: Academic Press
• Publication date: 1996
• ISBN 10: 0120329395
• ISBN 13: 9780120329397
• Binding: Hardcover
• Edition number: 1
• Number of pages: 707
• Editor: Packer Lester