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Lawrence K. Altman has pursued research on the subject of medical self-experimentation since his days as a medical student, and this personal interest shines throughout the book. His writing is smart and enthusiastic, shedding light on a little-discussed aspect of research that raises important questions of ethics and scientific validity. Can a researcher be as objective about his or her own reactions to a drug as to a stranger's reactions? Should a scientist subject others to risks that he or she wouldn't take personally? What, if anything, do we have to gain from self-experimentation?
As you might imagine, this book is not for the squeamish. Even if you're not put off by the ocean of body fluids, you may find the terrors of curare-induced paralysis or life under quarantine a bit troubling. Still, for those willing or eager to confront such details, Who Goes First? provides an outstanding, highly readable introduction to the rehumanization of medical research. --Rob Lightner
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