Anti-Human Galanin Receptor Antibodies: An Evaluation in Normal and Pathologic Tissues - Softcover
The neuropeptide galanin is involved in the regulation of several physiological processes, which are mediated via three different G-protein-coupled receptors (GPCRs). The galanin receptors show distinct but overlapping expression in the central nervous system and in the periphery. GPCRs have been described as major drug targets for various human diseases. Therefore, the determination of the cellular and subcellular localization of galanin receptors is of high interest. Antibodies are a valuable tool to study the distribution of receptors of interest. Even though there are several antibodies raised against the different galanin receptor subtypes commercially available, it has been demonstrated that lack of selectivity appears to be the rule rather than the exception for antibodies against these GPCRs. Therefore, the specificity of several commercially available antibodies to human galanin receptors was evaluated in immunoblotting and immunohistochemistry. One out of two anti-GalR1 antibodies, one out of two anti-GalR2 antibodies and one out of three tested anti-GalR3 antibodies showed specific staining in Western blot analysis and immunohistochemistry. Using these antibodies it was possible for the first time and in detail to illustrate the cellular expression and localization of the three galanin receptor subtypes in numerous normal and pathologic human tissues.
"synopsis" may belong to another edition of this title.
About the Author:
studied genetics and molecular biology at the University of Salzburg, Austria. After completing his master's thesis at the Laura Bassi Centre of Expertise – THERAPEP, Research Laboratory of the Children's Hospital Salzburg he started to work as a research associate for the Clinical Research Center Salzburg at the Children's Hospital to get his PhD.
"About this title" may belong to another edition of this title.
- PublisherAV Akademikerverlag
- Publication date2013
- ISBN 10 3639456033
- ISBN 13 9783639456035
- BindingPaperback
- Number of pages112
Buy New
Learn more about this copy
US$ 34.75
Shipping:
US$ 3.99
Within U.S.A.
Top Search Results from the AbeBooks Marketplace
Stock Image
Anti-Human Galanin Receptor Antibodies: An Evaluation in Normal and Pathologic Tissues
Published by
AV Akademikerverlag
(2013)
ISBN 10: 3639456033
ISBN 13: 9783639456035
New
Softcover
Quantity: > 20
Seller:
Rating
Book Description Condition: New. Seller Inventory # ABLIING23Mar3113020198741
Buy New
US$ 34.75
Convert currency
Stock Image
Anti-Human Galanin Receptor Antibodies
Published by
AV Akademikerverlag
(2013)
ISBN 10: 3639456033
ISBN 13: 9783639456035
New
Softcover
Quantity: > 20
Seller:
Rating
Book Description Condition: New. PRINT ON DEMAND Book; New; Fast Shipping from the UK. No. book. Seller Inventory # ria9783639456035_lsuk
Buy New
US$ 39.04
Convert currency
Stock Image
Anti-Human Galanin Receptor Antibodies
Published by
AV Akademikerverlag 2013-03
(2013)
ISBN 10: 3639456033
ISBN 13: 9783639456035
New
PF
Quantity: 10
Seller:
Rating
Book Description PF. Condition: New. Seller Inventory # 6666-IUK-9783639456035
Buy New
US$ 35.59
Convert currency
Stock Image
AntiHuman Galanin Receptor Antibodies An Evaluation in Normal and Pathologic Tissues
Published by
AV Akademikerverlag
(2013)
ISBN 10: 3639456033
ISBN 13: 9783639456035
New
PAP
Quantity: > 20
Seller:
Rating
Book Description PAP. Condition: New. New Book. Shipped from UK. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000. Seller Inventory # L0-9783639456035
Buy New
US$ 55.21
Convert currency
Seller Image
Anti-Human Galanin Receptor Antibodies
Published by
AV Akademikerverlag Mrz 2013
(2013)
ISBN 10: 3639456033
ISBN 13: 9783639456035
New
Taschenbuch
Quantity: 2
Seller:
Rating
Book Description Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The neuropeptide galanin is involved in the regulation of several physiological processes, which are mediated via three different G-protein-coupled receptors (GPCRs). The galanin receptors show distinct but overlapping expression in the central nervous system and in the periphery. GPCRs have been described as major drug targets for various human diseases. Therefore, the determination of the cellular and subcellular localization of galanin receptors is of high interest. Antibodies are a valuable tool to study the distribution of receptors of interest. Even though there are several antibodies raised against the different galanin receptor subtypes commercially available, it has been demonstrated that lack of selectivity appears to be the rule rather than the exception for antibodies against these GPCRs. Therefore, the specificity of several commercially available antibodies to human galanin receptors was evaluated in immunoblotting and immunohistochemistry. One out of two anti-GalR1 antibodies, one out of two anti-GalR2 antibodies and one out of three tested anti-GalR3 antibodies showed specific staining in Western blot analysis and immunohistochemistry. Using these antibodies it was possible for the first time and in detail to illustrate the cellular expression and localization of the three galanin receptor subtypes in numerous normal and pathologic human tissues. 112 pp. Englisch. Seller Inventory # 9783639456035
Buy New
US$ 36.86
Convert currency
Seller Image
Anti-Human Galanin Receptor Antibodies : An Evaluation in Normal and Pathologic Tissues
Published by
AV Akademikerverlag
(2013)
ISBN 10: 3639456033
ISBN 13: 9783639456035
New
Taschenbuch
Quantity: 1
Seller:
Rating
Book Description Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - The neuropeptide galanin is involved in the regulation of several physiological processes, which are mediated via three different G-protein-coupled receptors (GPCRs). The galanin receptors show distinct but overlapping expression in the central nervous system and in the periphery. GPCRs have been described as major drug targets for various human diseases. Therefore, the determination of the cellular and subcellular localization of galanin receptors is of high interest. Antibodies are a valuable tool to study the distribution of receptors of interest. Even though there are several antibodies raised against the different galanin receptor subtypes commercially available, it has been demonstrated that lack of selectivity appears to be the rule rather than the exception for antibodies against these GPCRs. Therefore, the specificity of several commercially available antibodies to human galanin receptors was evaluated in immunoblotting and immunohistochemistry. One out of two anti-GalR1 antibodies, one out of two anti-GalR2 antibodies and one out of three tested anti-GalR3 antibodies showed specific staining in Western blot analysis and immunohistochemistry. Using these antibodies it was possible for the first time and in detail to illustrate the cellular expression and localization of the three galanin receptor subtypes in numerous normal and pathologic human tissues. Seller Inventory # 9783639456035
Buy New
US$ 36.86
Convert currency
Stock Image
AntiHuman Galanin Receptor Antibodies An Evaluation in Normal and Pathologic Tissues
Published by
AV Akademikerverlag
(2013)
ISBN 10: 3639456033
ISBN 13: 9783639456035
New
PAP
Quantity: > 20
Seller:
Rating
Book Description PAP. Condition: New. New Book. Delivered from our UK warehouse in 4 to 14 business days. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000. Seller Inventory # L0-9783639456035
Buy New
US$ 41.52
Convert currency
Stock Image
Anti-Human Galanin Receptor Antibodies: An Evaluation in Normal and Pathologic Tissues
Published by
AV Akademikerverlag
(2013)
ISBN 10: 3639456033
ISBN 13: 9783639456035
New
Softcover
Quantity: 5
Seller:
Rating
Book Description Seller Inventory # STOCK12314853
Buy New
US$ 65.00
Convert currency
Seller Image
Anti-Human Galanin Receptor Antibodies
Published by
AV Akademikerverlag
(2013)
ISBN 10: 3639456033
ISBN 13: 9783639456035
New
Softcover
Quantity: > 20
Seller:
Rating
Book Description Condition: New. Seller Inventory # 4989785
Buy New
US$ 31.17
Convert currency