Development and Evaluation of Fast Dissolving Tablet of Loratadine: Using Solid Dispersion Technique - Softcover
Loratadine is a non sedative anti-histaminic drug. Its major use is in control of congestion, sneezing, runny nose and itching that a patient suffers with an allergic attack or an infection. It has poor solubility in water. Therefore, the solubility and drug release were enhanced using the solid dispersion technique and fast dissolving tablet were formulated. Solid dispersion prepared using Poloxamer 407, PEG 6000 and urea. The solid dispersion were evaluated for saturation solubility, drug content and in vitro dissolution study and it was characterized using FT-IR, X-RD, SEM and DSC study. The fast dissolving tablets of loratadine was formulated using crospovidone and crosscarmelose sodium by direct compression method. The tablets were evaluated for thickness, hardness, weight variation, friability, disintegration time and % in vitro drug release. A 32 factorial design was used to study the effect of Loratadine: Poloxamer 407 and crospovidone on disintegration time and % in vitro drug release. The responses were analyzed using ANOVA. The obtained model was validated & optimized formulation was prepared as suggested by the software.
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About the Author:
Nidhi Sherathiya, Master of Pharmacy, Pharmaceuticsat Gujarat Technological University, Pharmacy Scholar at S. J. Thakkar Pharmacy College, Rajkot, Gujarat, India.
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- PublisherLAP LAMBERT Academic Publishing
- Publication date2013
- ISBN 10 3659479780
- ISBN 13 9783659479786
- BindingPaperback
- Number of pages120
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Development and Evaluation of Fast Dissolving Tablet of Loratadine: Using Solid Dispersion Technique
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Development and Evaluation of Fast Dissolving Tablet of Loratadine Using Solid Dispersion Technique
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Book Description Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Loratadine is a non sedative anti-histaminic drug. Its major use is in control of congestion, sneezing, runny nose and itching that a patient suffers with an allergic attack or an infection. It has poor solubility in water. Therefore, the solubility and drug release were enhanced using the solid dispersion technique and fast dissolving tablet were formulated. Solid dispersion prepared using Poloxamer 407, PEG 6000 and urea. The solid dispersion were evaluated for saturation solubility, drug content and in vitro dissolution study and it was characterized using FT-IR, X-RD, SEM and DSC study. The fast dissolving tablets of loratadine was formulated using crospovidone and crosscarmelose sodium by direct compression method. The tablets were evaluated for thickness, hardness, weight variation, friability, disintegration time and % in vitro drug release. A 32 factorial design was used to study the effect of Loratadine: Poloxamer 407 and crospovidone on disintegration time and % in vitro drug release. The responses were analyzed using ANOVA. The obtained model was validated & optimized formulation was prepared as suggested by the software. 120 pp. Englisch. Seller Inventory # 9783659479786
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Development and Evaluation of Fast Dissolving Tablet of Loratadine : Using Solid Dispersion Technique
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Book Description Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Loratadine is a non sedative anti-histaminic drug. Its major use is in control of congestion, sneezing, runny nose and itching that a patient suffers with an allergic attack or an infection. It has poor solubility in water. Therefore, the solubility and drug release were enhanced using the solid dispersion technique and fast dissolving tablet were formulated. Solid dispersion prepared using Poloxamer 407, PEG 6000 and urea. The solid dispersion were evaluated for saturation solubility, drug content and in vitro dissolution study and it was characterized using FT-IR, X-RD, SEM and DSC study. The fast dissolving tablets of loratadine was formulated using crospovidone and crosscarmelose sodium by direct compression method. The tablets were evaluated for thickness, hardness, weight variation, friability, disintegration time and % in vitro drug release. A 32 factorial design was used to study the effect of Loratadine: Poloxamer 407 and crospovidone on disintegration time and % in vitro drug release. The responses were analyzed using ANOVA. The obtained model was validated & optimized formulation was prepared as suggested by the software. Seller Inventory # 9783659479786
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Development and Evaluation of Fast Dissolving Tablet of Loratadine Using Solid Dispersion Technique
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ISBN 13: 9783659479786
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Development and Evaluation of Fast Dissolving Tablet of Loratadine
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Book Description Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Sherathiya NidhiNidhi Sherathiya, Master of Pharmacy, Pharmaceuticsat Gujarat Technological University, Pharmacy Scholar at S. J. Thakkar Pharmacy College, Rajkot, Gujarat, India.Loratadine is a non sedative anti-histaminic drug. Seller Inventory # 5158664
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