Production of Lovastatin by Fungi: Solid state fermentation using agro-industrial residues - Softcover

Latha, Dunga Prasanna; Hemalatha, K.P.J.

Softcover

ISBN 10: 3659795720 ISBN 13: 9783659795725

Publisher: LAP LAMBERT Academic Publishing, 2016

Synopsis

The present book is aimed to screen the potent lovastatin producing pair from a variety of solid substrates and fungal organisms. Lovastatin is a potent competitive inhibitor of HMG-CoA reductase, a microsomal enzyme that catalyzes the conversion of the substrates HMG-CoA to mevalonate. This enzyme has a significant role in the synthesis of cholesterol. Besides this, lovastatin has many biomedical applications. Lovastatin yield can be increased through solid state fermentation when compared to submerged fermentation and very few works have been carried oaut for the production of lovastatin through SSF. Substrates not used earlier were used to study the production of lovastatin. The work is planned under the five following objectives: 1.Screening of potential Lovastatin producing Fungal organisms and Solid substrates. 2.Optimizing the Process parameters and Nutrient parameters to increase the Lovastatin producing potential. 3.To immobilize Penicillium funiculosum by entrapment method. 4.Strain Improvement by using Physical and Chemical mutagens for better lovastatin production. 5.Antimicrobial activity of Lovastatin was performed to evaluate the antimicrobial activity.

About this title

About the Author:

Dr.D.Prasanna Latha pursued M.Sc.,Ph.D in Microbiology at Andhra University,Andhra Pradesh,India.She is working as a faculty in the Department of Microbiology,A.U.Prof.K.P.J.Hemalatha is the Head of the Department of Microbiology, A.U. She is the Selection Board member and Adjudicator for Ph.D thesis of various Universities in India

About this edition

• Publisher: LAP LAMBERT Academic Publishing
• Publication date: 2016
• ISBN 10: 3659795720
• ISBN 13: 9783659795725
• Binding: Paperback
• Number of pages: 228