KineticStudy of Diclofenac Sodium from MethocelK15MCR and Cetylalcohol: Using Model dependent and Independent Methods and Bioequivalence Study - Softcover
Current study aimed at the development of a matrix type sustain release Diclofenac tablet, using hydrophilic HPMC and hydrophobic polymer Cetyl alcohol. It was found that hydrophilic Methocel K15 MCRŽ matrices based tablets showed zero order and hydrophobic cetyl alcohol matrices based tablets were followed first-order kinetics except formulation six (F6 showed zero order profile). The result of dissolution study indicated that formulations containing cetyl alcohol showed better dissolution properties as compared to formulations containing Methocel K15 MCRŽ in terms of similarity and difference factor. By comparing the dissolution profiles with Voltaren SRŽ tablet in terms of difference factors and similarity factors, it was revealed that the formulation F-4, F-5 and F-6 exhibited similar drug release profile as that of Voltaren SRŽ tablet which indicated that these formulations could be bioequivalent with Voltaren SRŽ tablet in vitro. The present study demonstrated that Diclofenac could be successfully prepared using an appropriate amount of Methocel K15 MCRŽ and cetyl alcohol in the form of matrix tablets with similar dissolution profile of patent product Voltaren SRŽ.
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About the Author:
Md. Imamul Islam, MS in Pharmaceutical Science, Jahangirnagar University, Savar, Dhaka-1342,Researcher in the Protein Biochemistry Laboratory, Chosun University, South Korea.
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- PublisherLAP LAMBERT Academic Publishing
- Publication date2012
- ISBN 10 3844386297
- ISBN 13 9783844386295
- BindingPaperback
- Number of pages92
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KineticStudy of Diclofenac Sodium from MethocelK15MCR and Cetylalcohol: Using Model dependent and Independent Methods and Bioequivalence Study
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KineticStudy of Diclofenac Sodium from MethocelK15MCR and Cetylalcohol Using Model dependent and Independent Methods and Bioequivalence Study
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Book Description Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Current study aimed at the development of a matrix type sustain release Diclofenac tablet, using hydrophilic HPMC and hydrophobic polymer Cetyl alcohol. It was found that hydrophilic Methocel K15 MCRŽ matrices based tablets showed zero order and hydrophobic cetyl alcohol matrices based tablets were followed first-order kinetics except formulation six (F6 showed zero order profile). The result of dissolution study indicated that formulations containing cetyl alcohol showed better dissolution properties as compared to formulations containing Methocel K15 MCRŽ in terms of similarity and difference factor. By comparing the dissolution profiles with Voltaren SRŽ tablet in terms of difference factors and similarity factors, it was revealed that the formulation F-4, F-5 and F-6 exhibited similar drug release profile as that of Voltaren SRŽ tablet which indicated that these formulations could be bioequivalent with Voltaren SRŽ tablet in vitro. The present study demonstrated that Diclofenac could be successfully prepared using an appropriate amount of Methocel K15 MCRŽ and cetyl alcohol in the form of matrix tablets with similar dissolution profile of patent product Voltaren SRŽ. 92 pp. Englisch. Seller Inventory # 9783844386295
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KineticStudy of Diclofenac Sodium from MethocelK15MCR and Cetylalcohol : Using Model dependent and Independent Methods and Bioequivalence Study
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Book Description Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Current study aimed at the development of a matrix type sustain release Diclofenac tablet, using hydrophilic HPMC and hydrophobic polymer Cetyl alcohol. It was found that hydrophilic Methocel K15 MCRŽ matrices based tablets showed zero order and hydrophobic cetyl alcohol matrices based tablets were followed first-order kinetics except formulation six (F6 showed zero order profile). The result of dissolution study indicated that formulations containing cetyl alcohol showed better dissolution properties as compared to formulations containing Methocel K15 MCRŽ in terms of similarity and difference factor. By comparing the dissolution profiles with Voltaren SRŽ tablet in terms of difference factors and similarity factors, it was revealed that the formulation F-4, F-5 and F-6 exhibited similar drug release profile as that of Voltaren SRŽ tablet which indicated that these formulations could be bioequivalent with Voltaren SRŽ tablet in vitro. The present study demonstrated that Diclofenac could be successfully prepared using an appropriate amount of Methocel K15 MCRŽ and cetyl alcohol in the form of matrix tablets with similar dissolution profile of patent product Voltaren SRŽ. Seller Inventory # 9783844386295
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KineticStudy of Diclofenac Sodium from MethocelK15MCR and Cetylalcohol Using Model dependent and Independent Methods and Bioequivalence Study
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ISBN 13: 9783844386295
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KineticStudy of Diclofenac Sodium from MethocelK15MCR and Cetylalcohol
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Book Description Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Islam Md. ImamulMd. Imamul Islam, MS in Pharmaceutical Science, Jahangirnagar University, Savar, Dhaka-1342,Researcher in the Protein Biochemistry Laboratory, Chosun University, South Korea.Current study aimed at the development . Seller Inventory # 5476147
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