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El Inhibidor de La Autofagia: 3-Metiladenina

Romina Hermann

Published by Ewe Editorial Acad MIA Espa Ola
ISBN 10: 3659039209 / ISBN 13: 9783659039201
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Title: El Inhibidor de La Autofagia: 3-Metiladenina

Publisher: Ewe Editorial Acad MIA Espa Ola

Binding: Paperback

Book Condition: New

Book Type: Paperback

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Paperback. 60 pages. Dimensions: 8.7in. x 5.9in. x 0.1in.La autofagia (AF) es un proceso que participa en el recambio de protenas de vida media larga y de organelas, especialmente mitocondrias disfuncionales. Este proceso es rpidamente activado bajo condiciones de privacin de nutrientes e hipoxia como ocurre en situaciones de isquemia, pudiendo la remocin de mitocondrias daadas durante el proceso de AF representar un mecanismo protector en el corazn sometido a isquemia-reperfusin. Las publicaciones sobre el tema son escasas y contradictorias, por lo que se desprende la importancia de investigar el papel desempeado por la AF en la injuria por isquemia-reperfusin. El objetivo del presente trabajo fue evaluar los efectos del inhibidor de la AF, 3-metiladenina (MA), en la recuperacin funcional post-isqumica, la preservacin de la viabilidad celular y la morfologa mitocondrial en aurculas de rata sometidas a isquemia reperfusin simuladas (Is-Rs). Los resultados muestran un mayor desarrollo de contractura durante la isquemia y la reperfusin temprana, generacin de arritmias severas durante la reperfusin, alteraciones significativas en la morfologa mitocondrial y una menor reserva contrctil luego de la Is-Rs en presencia de MA This item ships from multiple locations. Your book may arrive from Roseburg,OR, La Vergne,TN. Bookseller Inventory # 9783659039201

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