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Synthesis and Biological Testing of 1-Adamantyl Derivatives

Ebtehal AlAbdullah

Published by VDM Verlag
ISBN 10: 3639246705 / ISBN 13: 9783639246704
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Title: Synthesis and Biological Testing of 1-...

Publisher: VDM Verlag

Binding: Paperback

Book Condition: New

Book Type: Paperback


Paperback. 176 pages. Dimensions: 8.7in. x 5.9in. x 0.4in.Several adamantane derivatives have long been known for diverse biological properties, mainly as antiviral, antibacterial, antifungal and anti-inflammatory agents. adamantyl derivatives were recently reported to possess 11-HSD1 inhibitory activities. In addition, 1, 2, 4-triazole and 1, 3, 4-thiadiazole were reported to constitute the pharmacologically active moiety of several compounds. On these bases new series of 1-adamantyl derivatives, in which the adamantyl moiety was attached to 1, 2, 4-triazole, 1, 2, 4-triazolo3, 4-b1, 3, 4thiadiazole or 1, 3, 4-thiadiazole nucleus, have been synthesized as potential bioactive agents All the synthesized compounds were tested for their in vitro growth inhibitory activity against a panel of standard strains of pathogenic microorganism including Gram-positive bacteria, Gram-negative bacteria and the yeast-like pathogenic fungus Candida albicans. In addition, the acute anti-inflammatory activity of a representative compounds was determined in vivo following the carrageenan-induced paw oedema method in rats. This item ships from multiple locations. Your book may arrive from Roseburg,OR, La Vergne,TN. Bookseller Inventory # 9783639246704

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