Detection of some AML Fusion Genes by Molecular Biology Technique: Haematological Malignancies - Softcover
The diagnosis, prognosis, and treatment of acute myeloid leukemia (AML) has been transformed over the past 15 years from a disease defined, classed, and staged based on histologic characteristics alone to a disease classified largely based on genetic, genomic, and molecular characteristics. The risk pattern in AML is determined not only by cytogenetic abnormalities, such as chromosomal deletions, duplications, or substitutions, but also by the elucidation of certain molecular mutations leading to over- or under-expressions of one of many proteins.This book was aimed to detect the three most frequently occurring reciprocal translocations of(AML) by reverse transcriptase polymerase chain reaction (RT-PCR): AML1-ETO associated with t(8;21), CBFB-MYH11 with inv(16), PML-RARA with t(15;17). The incidence of the common fusion transcripts in our pilot study is in accordance with that described in western studies. It is important to identify these transcripts as they provide useful prognostic information to the treating clinician.This study helps to establish the RT-PCR technique for the first time in the detection of these AML fusion genes,in the molecular biology department in Sudan.
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About the Author:
BSc (MLS), Qualifying year, Institute of Endemic Disease Khartoum University, MSc in Molecular Biology,2013. Worked as Chief Tech. in Molecular Biology Dept (RICK). 2008 received training course in Western General Hospital in Molecular Biology Dept, Edinburgh,UK .Currently CEO in Drive Health Int. Co & Flow cytometry Centre.
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- PublisherLAP LAMBERT Academic Publishing
- Publication date2013
- ISBN 10 3659446815
- ISBN 13 9783659446818
- BindingPaperback
- Number of pages88
- EditorOsman Ihsan, Abdel Gader Abdel Muhsin
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Detection of Some AML Fusion Genes by Molecular Biology Technique
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Detection of some AML Fusion Genes by Molecular Biology Technique: Haematological Malignancies
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Book Description Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The diagnosis, prognosis, and treatment of acute myeloid leukemia (AML) has been transformed over the past 15 years from a disease defined, classed, and staged based on histologic characteristics alone to a disease classified largely based on genetic, genomic, and molecular characteristics. The risk pattern in AML is determined not only by cytogenetic abnormalities, such as chromosomal deletions, duplications, or substitutions, but also by the elucidation of certain molecular mutations leading to over- or under-expressions of one of many proteins.This book was aimed to detect the three most frequently occurring reciprocal translocations of(AML) by reverse transcriptase polymerase chain reaction (RT-PCR): AML1-ETO associated with t(8;21), CBFB-MYH11 with inv(16), PML-RARA with t(15;17). The incidence of the common fusion transcripts in our pilot study is in accordance with that described in western studies. It is important to identify these transcripts as they provide useful prognostic information to the treating clinician.This study helps to establish the RT-PCR technique for the first time in the detection of these AML fusion genes,in the molecular biology department in Sudan. 88 pp. Englisch. Seller Inventory # 9783659446818
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Detection of some AML Fusion Genes by Molecular Biology Technique : Haematological Malignancies
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Book Description Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - The diagnosis, prognosis, and treatment of acute myeloid leukemia (AML) has been transformed over the past 15 years from a disease defined, classed, and staged based on histologic characteristics alone to a disease classified largely based on genetic, genomic, and molecular characteristics. The risk pattern in AML is determined not only by cytogenetic abnormalities, such as chromosomal deletions, duplications, or substitutions, but also by the elucidation of certain molecular mutations leading to over- or under-expressions of one of many proteins.This book was aimed to detect the three most frequently occurring reciprocal translocations of(AML) by reverse transcriptase polymerase chain reaction (RT-PCR): AML1-ETO associated with t(8;21), CBFB-MYH11 with inv(16), PML-RARA with t(15;17). The incidence of the common fusion transcripts in our pilot study is in accordance with that described in western studies. It is important to identify these transcripts as they provide useful prognostic information to the treating clinician.This study helps to establish the RT-PCR technique for the first time in the detection of these AML fusion genes,in the molecular biology department in Sudan. Seller Inventory # 9783659446818
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Detection of some AML Fusion Genes by Molecular Biology Technique Haematological Malignancies
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Detection of some AML Fusion Genes by Molecular Biology Technique
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Book Description Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Abbass EmanBSc (MLS), Qualifying year, Institute of Endemic Disease Khartoum University, MSc in Molecular Biology,2013. Worked as Chief Tech. in Molecular Biology Dept (RICK). 2008 received training course in Western General Hospital. Seller Inventory # 5156757
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