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Downregulation of Endogenous Trail and Its Effect on Cancer Cells

Sara Brittingham

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ISBN 10: 3838131053 / ISBN 13: 9783838131054
Published by Sudwestdeutscher Verlag Fur Hochschulschriften AG
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84 pages. Dimensions: 8.7in. x 5.9in. x 0.2in.Clinical studies report that increased expression of endogenous tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is associated with decreased disease-specific survival in cancers which are resistant to TRAIL induced apoptosis. The present work investigated the role of endogenous TRAIL as an intrinsic growth factor in apoptosis-resistant human cancer cells. This less-well known effect of TRAIL was studied in the neuroblastoma cell line KELLY, a cancer cell line with intrinsic resistance to TRAIL-induced apoptosis. The functional impact of the knockdown of endogenous TRAIL was investigated by measuring cell growth and cell death after transfection: Interestingly, KELLY cells unexpectedly showed markedly reduced cell growth upon knockdown of endogenous TRAIL. Furthermore, knockdown of TRAIL induced cell death in KELLY cells, which was dependent on caspase-signaling and rescued by the addition of soluble TRAIL. Thus, the present work provided first evidence that endogenous TRAIL functions as an intrinsic survival and growth factor in KELLY cells and supports the potential of endogenous TRAIL to function as a novel therapeutic target in cancer therapy. This item ships from multiple locations. Your book may arrive from Roseburg,OR, La Vergne,TN. Bookseller Inventory # 9783838131054

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Bibliographic Details

Title: Downregulation of Endogenous Trail and Its ...

Publisher: Sudwestdeutscher Verlag Fur Hochschulschriften AG

Binding: Paperback

Book Condition:New

Book Type: Paperback

About this title

Synopsis:

Clinical studies report that increased expression of endogenous tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is associated with decreased disease-specific survival in cancers which are resistant to TRAIL induced apoptosis. The present work investigated the role of endogenous TRAIL as an intrinsic growth factor in apoptosis-resistant human cancer cells. This less-well known effect of TRAIL was studied in the neuroblastoma cell line KELLY, a cancer cell line with intrinsic resistance to TRAIL-induced apoptosis. The functional impact of the knockdown of endogenous TRAIL was investigated by measuring cell growth and cell death after transfection: Interestingly, KELLY cells unexpectedly showed markedly reduced cell growth upon knockdown of endogenous TRAIL. Furthermore, knockdown of TRAIL induced cell death in KELLY cells, which was dependent on caspase-signaling and rescued by the addition of soluble TRAIL. Thus, the present work provided first evidence that endogenous TRAIL functions as an intrinsic survival and growth factor in KELLY cells and supports the potential of endogenous TRAIL to function as a novel therapeutic target in cancer therapy.

About the Author:

born in Warsaw 1982, she studied Medicine at the TU Munich from 2003-2010. Clinical electives at Johns Hopkins University in Baltimore and New York Presbyterian Hospital were followed by research in the department of gene vectors at the German Research Center for Environmental Health. Since 2011 physician at Bern University Hospital in Switzerland.

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