Published by Springer International Publishing, 2016
ISBN 10: 3319289004 ISBN 13: 9783319289007
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Published by Springer, 2016
ISBN 10: 3319289004 ISBN 13: 9783319289007
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Published by Springer, 2016
ISBN 10: 3319289004 ISBN 13: 9783319289007
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Published by Springer, 2016
ISBN 10: 3319289004 ISBN 13: 9783319289007
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ISBN 10: 3319289004 ISBN 13: 9783319289007
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ISBN 10: 3319804537 ISBN 13: 9783319804538
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ISBN 10: 3319289004 ISBN 13: 9783319289007
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Published by Springer International Publishing Feb 2016, 2016
ISBN 10: 3319289004 ISBN 13: 9783319289007
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Buch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This work represents an inventive attempt to apply recent advances in nanotechnology to identify and characterise novel polymer systems for drug delivery through the skin. Atomic force microscopy (AFM) measurements of the nanoscale mechanical properties of topical, drug-containing polymeric films enabled the author to identify optimal compositions, in terms of flexibility and substantivity, for application to the skin. To elucidate the enhanced drug release from polyacrylate films incorporating medium chain triglycerides, the author combined AFM studies with the complementary technique of Raman micro-spectroscopy. This experimental strategy revealed that the significant increase in the drug released from these films is the result of a nanoscale two-phase structure. Finally, in experiments examining the microporation of skin using femtosecond laser ablation, the author demonstrated that the threshold at which the skin's barrier function is undermined can be dramatically reduced by the pre-application of ink. The approach allows thermal damage at the pore edge to be minimised, suggesting a very real potential for substantially increasing drug delivery in a minimally invasive fashion. 132 pp. Englisch.
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ISBN 10: 3319804537 ISBN 13: 9783319804538
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Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This work represents an inventive attempt to apply recent advances in nanotechnology to identify and characterise novel polymer systems for drug delivery through the skin. Atomic force microscopy (AFM) measurements of the nanoscale mechanical properties of topical, drug-containing polymeric films enabled the author to identify optimal compositions, in terms of flexibility and substantivity, for application to the skin. To elucidate the enhanced drug release from polyacrylate films incorporating medium chain triglycerides, the author combined AFM studies with the complementary technique of Raman micro-spectroscopy. This experimental strategy revealed that the significant increase in the drug released from these films is the result of a nanoscale two-phase structure. Finally, in experiments examining the microporation of skin using femtosecond laser ablation, the author demonstrated that the threshold at which the skin's barrier function is undermined can be dramatically reduced by the pre-application of ink. The approach allows thermal damage at the pore edge to be minimised, suggesting a very real potential for substantially increasing drug delivery in a minimally invasive fashion. 114 pp. Englisch.
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ISBN 10: 3319289004 ISBN 13: 9783319289007
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ISBN 10: 3319289004 ISBN 13: 9783319289007
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Published by Springer International Publishing, 2016
ISBN 10: 3319289004 ISBN 13: 9783319289007
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Buch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - This work represents an inventive attempt to apply recent advances in nanotechnology to identify and characterise novel polymer systems for drug delivery through the skin. Atomic force microscopy (AFM) measurements of the nanoscale mechanical properties of topical, drug-containing polymeric films enabled the author to identify optimal compositions, in terms of flexibility and substantivity, for application to the skin. To elucidate the enhanced drug release from polyacrylate films incorporating medium chain triglycerides, the author combined AFM studies with the complementary technique of Raman micro-spectroscopy. This experimental strategy revealed that the significant increase in the drug released from these films is the result of a nanoscale two-phase structure. Finally, in experiments examining the microporation of skin using femtosecond laser ablation, the author demonstrated that the threshold at which the skin's barrier function is undermined can be dramatically reduced by the pre-application of ink. The approach allows thermal damage at the pore edge to be minimised, suggesting a very real potential for substantially increasing drug delivery in a minimally invasive fashion.
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ISBN 10: 3319804537 ISBN 13: 9783319804538
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Taschenbuch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - This work represents an inventive attempt to apply recent advances in nanotechnology to identify and characterise novel polymer systems for drug delivery through the skin. Atomic force microscopy (AFM) measurements of the nanoscale mechanical properties of topical, drug-containing polymeric films enabled the author to identify optimal compositions, in terms of flexibility and substantivity, for application to the skin. To elucidate the enhanced drug release from polyacrylate films incorporating medium chain triglycerides, the author combined AFM studies with the complementary technique of Raman micro-spectroscopy. This experimental strategy revealed that the significant increase in the drug released from these films is the result of a nanoscale two-phase structure. Finally, in experiments examining the microporation of skin using femtosecond laser ablation, the author demonstrated that the threshold at which the skin's barrier function is undermined can be dramatically reduced by the pre-application of ink. The approach allows thermal damage at the pore edge to be minimised, suggesting a very real potential for substantially increasing drug delivery in a minimally invasive fashion.
Published by Springer International Publishing AG, 2016
ISBN 10: 3319289004 ISBN 13: 9783319289007
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Condition: New. Series: Springer Theses. Num Pages: 132 pages, 24 black & white illustrations, 25 colour illustrations, biography. BIC Classification: MMPH; MQW; PNNP; TBN. Category: (G) General (US: Trade). Dimension: 235 x 155 x 10. Weight in Grams: 369. . 2016. 1st ed. 2016. Hardback. . . . .
Published by Springer, 2018
ISBN 10: 3319804537 ISBN 13: 9783319804538
Seller: Kennys Bookshop and Art Galleries Ltd., Galway, GY, Ireland
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Published by Springer, 2016
ISBN 10: 3319289004 ISBN 13: 9783319289007
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Published by Springer International Publishing AG, 2016
ISBN 10: 3319289004 ISBN 13: 9783319289007
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Condition: New. Series: Springer Theses. Num Pages: 132 pages, 24 black & white illustrations, 25 colour illustrations, biography. BIC Classification: MMPH; MQW; PNNP; TBN. Category: (G) General (US: Trade). Dimension: 235 x 155 x 10. Weight in Grams: 369. . 2016. 1st ed. 2016. Hardback. . . . . Books ship from the US and Ireland.
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