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Molecular structure of deoxyribonucleic acid (DNA)
Publication Date: 1957
Seller: Jeremy Norman's historyofscience, Novato, CA, U.S.A.
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First Edition Signed
Langridge, Robert (1933- ); Seeds, W. E.; Wilson, H. R. (1929- ); Hooper, C. W.; Wilkins, Maurice (1916- ); and Hamilton, L. D. Molecular structure of deoxyribonucleic acid (DNA). Offprint from J. Biophys. & Biochem. Cytology 3 (1957). 767-778pp. Illustrated. 254 x 177 mm. Without wrappers as issued. Slight wear along spine, otherwise a fine copy, signed by Wilson on the first page. First Separate Edition. Further studies on both the A and B configuration of the DNA molecule, the A configuration existing when relative humidity of the atmosphere surrounding a fiber consisting of a DNA salt is reduced from 90-85 percent to 75 percent, and the B configuration existing when the DNA molecule is bound to protein in cells. An IBM computer was used to process some of the data; Langridge, the lead author of this paper and Wilkins's doctoral student, was the first to apply a stored-program digital computer to the analysis of DNA structure (as recorded in Langridge's PhD. dissertation, published the same year as the present paper).
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The molecular configuration of deoxyribonucleic acid (2 parts). Inscribed by Wilkins & Langridge
Publication Date: 1960
Seller: Jeremy Norman's historyofscience, Novato, CA, U.S.A.
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Inscribed by Langridge and Wilkins Langridge, Robert (1933- ); Wilson, H. R. (1929- ); Hooper, C. W.; Wilkins, Maurice (1916- ); and Hamilton, L. D. The molecular configuration of deoxyribonucleic acid. I. X-ray diffraction study of a crystalline form of the lithium salt. Offprint from J. Molecular Biol. 2 (1960). 20pp. Plate, text illustrations. With: Langridge, Robert (1933- ); Marvin, D. A.; Seeds, W. E.; Wilson, H. R. (1929- ); Hooper, C. W.; Wilkins, Maurice (1916- ); and Hamilton, L. D. The molecular configuration of deoxyribonucleic acid. II. Molecular models and their Fourier transforms. Offprint from J. Molecular Biol. 2 (1960). [1], 38-64pp. Plate, text illustrations. Together 2 items. 254 x 172 mm. Original printed self-wrappers. Fine copies, inscribed by Langridge ("Regards, Bob") and Wilkins ("M. H. F. Wilkins") on the front wrappers. . First Separate Editions. The first part of this paper presents an analysis of the x-ray diffraction patterns given by the lithium salt of DNA (LiDNA), "from which it may be deduced that the DNA molecule is helical with pitch 34 , probably contains two polynucleotide chains, and that each chain contains 10 nucleotides per turn. This configuration is known as the B type and exists in unfixed cell nuclei" (p. 2). The second part contains a correction of the Watson-Crick DNA molecular model based on calculations of the Fourier transform of DNA's molecular structure. An appendix to this part, by Langridge and two co-authors, describes how the Fourier transforms were calculated using an IBM 650 digital computer. Langridge, who obtained his doctorate in crystallography from the University of London under Maurice Wilkins's supervision, was the first to apply a stored program digital computer to the analysis of DNA structure, as described in his PhD. thesis (1957). .
